DC pole | Wartość | Język |
dc.contributor.author | Wielkoszyński, Tomasz | - |
dc.contributor.author | Zalejska-Fiolka, Jolanta | - |
dc.contributor.author | Strzelczyk, Joanna K. | - |
dc.contributor.author | Owczarek, Aleksander J. | - |
dc.contributor.author | Cholewka, Armand | - |
dc.contributor.author | Krawczyk, Aneta | - |
dc.contributor.author | Stanek, Agata | - |
dc.date.accessioned | 2019-11-18T19:10:24Z | - |
dc.date.available | 2019-11-18T19:10:24Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Oxidative Medicine and Cellular Longevity, vol. 2019, Art. Id. 1983975 | pl_PL |
dc.identifier.issn | 1942-0900 | - |
dc.identifier.issn | 1942-0994 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.12128/11660 | - |
dc.description.abstract | Objective. Cholesterol oxidation products have an established proatherogenic and cytotoxic effect. An increased exposure to these
substances may be associated with the development of atherosclerosis and cancers. Relatively little, though, is known about the
effect of phytosterol oxidation products, although phytosterols are present in commonly available and industrial food products.
Thus, the aim of the research was to assess the effect of 5α,6α-epoxyphytosterols, which are important phytosterol oxidation
products, on redox state in rats. Material and Methods. The animals were divided into 3 groups and exposed to nutritional
sterols by receiving feed containing 5α,6α-epoxyphytosterols (ES group) and 5α,6α-epoxycholesterol (Ech group) or sterol-free
feed (C group). The levels of malondialdehyde (MDA), conjugated dienes (CD), and ferric reducing antioxidant potential
(FRAP) were assayed in the plasma; anti-7-ketocholesterol antibodies and activity of paraoxonase-1 (PON1) were determined in
serum, whereas the activity of catalase (CAT), glutathione reductase (GR), glutathione peroxidase (GPx), S-glutathione
transferase (GST), and superoxide dismutase (SOD) were assayed in RBCs. Results. During the experiment, the levels of lipid
peroxidation products increased, such as CD and anti-7-ketocholesterol antibodies. At the same time, the plasma levels of FRAP
and serum activity of PON1 decreased alongside the reduced activity of GPx, GR, and SOD in RBCs. There was no effect of the
studied compounds on the plasma MDA levels or on the activity of CAT and GST in RBCs. Conclusions. Both 5α,6α-
epoxyphytosterols and 5α,6α-epoxycholesterols similarly dysregulate the redox state in experimental animal model and may
significantly impact atherogenesis. | pl_PL |
dc.language.iso | en | pl_PL |
dc.rights | Uznanie autorstwa 3.0 Polska | * |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/pl/ | * |
dc.subject | Low-Cholesterol Diet | pl_PL |
dc.subject | Cholesterol | pl_PL |
dc.title | 5α,6α-Epoxyphytosterols and 5α,6α-Epoxycholesterol Increase Oxidative Stress in Rats on Low-Cholesterol Diet | pl_PL |
dc.type | info:eu-repo/semantics/article | pl_PL |
dc.identifier.doi | 10.1155/2019/1983975 | - |
Pojawia się w kolekcji: | Artykuły (WNŚiT)
|