http://hdl.handle.net/20.500.12128/12339
Title: | Antifungal styryloquinolines as Candida albicans efflux pump inhibitors : styryloquinolines are ABC transporter inhibitors |
Authors: | Cieślik, Wioleta Szczepaniak, Joanna Krasowska, Anna Musioł, Robert |
Keywords: | styrylquinolines; Candida albicans; ABC transporters; Cdr1p |
Issue Date: | 2020 |
Citation: | "Molecules (Basel)" iss. 2 (2020), art. no 345, s. 1-12 |
Abstract: | Styrylquinolines are heterocyclic compounds that are known for their antifungal and antimicrobial activity. Metal complexation through hydroxyl groups has been claimed to be a plausible mechanism of action for these types of compounds. A series of novel structures with protected hydroxyl groups have been designed and synthesized to verify the literature data. Their antifungal activity against wild-type Candida albicans strain and mutants with silenced efflux pumps activity has been determined. Combinations with fluconazole revealed synergistic interactions that were dependent on the substitution pattern. These results open a new route for designing active antifungal agents on a styrylquinoline scaffold. |
URI: | http://hdl.handle.net/20.500.12128/12339 |
DOI: | 10.3390/molecules25020345 |
ISSN: | 1420-3049 |
Appears in Collections: | Artykuły (WNŚiT) |
File | Description | Size | Format | |
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Cieslik_Antifungal_styryloquinolines_as_Candida_albicans_efflux_pump_inhibitors.pdf | 1,15 MB | Adobe PDF | View/Open |
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