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Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12128/16363
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dc.contributor.authorChmiel, Krzysztof-
dc.contributor.authorKnapik-Kowalczuk, Justyna-
dc.contributor.authorPaluch, Marian-
dc.date.accessioned2020-10-07T11:46:04Z-
dc.date.available2020-10-07T11:46:04Z-
dc.date.issued2020-
dc.identifier.citation"Molecular Pharmaceutics" vol. 17, iss. 10 (2020), s. 3730-3739pl_PL
dc.identifier.issn1543-8384-
dc.identifier.issn1543-8392-
dc.identifier.urihttp://hdl.handle.net/20.500.12128/16363-
dc.description.abstractIn this work, we proposed the method to maintain the desired level of drug’s solubility within the polymer matrix by adjusting conditions to uphold the same molecular dynamics of the system (e.g., temperature for set elevated pressure or vice versa). Namely, we observed, that recrystallization of the drug from the supersaturated drug−polymer system, initiated for the same structural relaxation time of the sample (τα‑1) ceases when certain, different than the initial, molecular mobility of the systems is reached (τα‑2)regardless of a given combination of temperature and pressure conditions. Based on the presented results, one can conclude that the molecular dynamics seem to control the process of recrystallization of the excess amount of solute from the supersaturated solution (e.g., small molecules dissolved within the polymer). Therefore, it appears that the elevated pressure compensates the effect of solubility enhancement caused by the elevated temperature. Such information not only is of fundamental relevance in science but also, from a much broader perspective, could be potentially very useful considering extrusion-based manufacturing methods.pl_PL
dc.language.isoenpl_PL
dc.rightsUznanie autorstwa 3.0 Polska*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/pl/*
dc.subjectASDpl_PL
dc.subjectdielectric spectroscopypl_PL
dc.subjectsolubilitypl_PL
dc.subjecthigh-pressurepl_PL
dc.subjectflutamidepl_PL
dc.subjectKollidon VA64pl_PL
dc.titleIsochronal conditions - the key to maintain the given solubility limit, of a small molecule within the polymer matrix, at elevated pressurepl_PL
dc.typeinfo:eu-repo/semantics/articlepl_PL
dc.identifier.doi10.1021/acs.molpharmaceut.0c00463-
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