http://hdl.handle.net/20.500.12128/18018
Tytuł: | An Organic–Inorganic Hybrid Nanocomposite as a Potential New Biological Agent |
Autor: | Dulski, Mateusz Malarz, Katarzyna Kuczak, Michał Dudek, Karolina Matus, Krzysztof Sułowicz, Sławomir Mrozek-Wilczkiewicz, Anna Nowak, Anna |
Słowa kluczowe: | chemical reduction; silver-silica nanocomposite; carboxymethylcellulose; sodium alginate; physicochemical features; antimicrobial activity; anticancer activity; colon cancer; breast cancer; pancreatic cancer; glioblastoma |
Data wydania: | 2020 |
Źródło: | "Nanomaterials" (2020), iss. 10, art. no. 2551, s. 1-24 |
Abstrakt: | To solve the problem of human diseases caused by a combination of genetic and environmental factors or by microorganisms, intense research to find completely new materials is required. One of the promising systems in this area is the silver-silica nanocomposites and their derivatives. Hence, silver and silver oxide nanoparticles that were homogeneously distributed within a silica carrier were fabricated. Their average size was d = (7.8 0.3) nm. The organic polymers (carboxymethylcellulose (CMC) and sodium alginate (AS)) were added to improve the biological features of the nanocomposite. The first system was prepared as a silver chlorine salt combination that was immersed on a silica carrier with coagulated particles whose size was d = (44.1 2.3) nm, which coexisted with metallic silver. The second system obtained was synergistically interacted metallic and oxidized silver nanoparticles that were distributed on a structurally defective silica network. Their average size was d = (6.6 0.7) nm. Physicochemical and biological experiments showed that the tiny silver nanoparticles in Ag/SiO2 and Ag/SiO2@AS inhibited E. coli, P. aeruginosa, S. aureus, and L. plantarum’s cell growth as well as caused a high anticancer e ect. On the other hand, the massive silver nanoparticles of Ag/SiO2@CMC had a weaker antimicrobial e ect, although they highly interacted against PANC-1. They also generated reactive oxygen species (ROS) as well as the induction of apoptosis via the p53-independent mechanism. |
URI: | http://hdl.handle.net/20.500.12128/18018 |
DOI: | 10.3390/nano10122551 |
ISSN: | 2079-4991 |
Pojawia się w kolekcji: | Artykuły (WNŚiT) |
Plik | Opis | Rozmiar | Format | |
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Dulski_Malarz_an_organic_inorganic_hybrid.pdf | 3,37 MB | Adobe PDF | Przejrzyj / Otwórz |
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