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Title: An Organic–Inorganic Hybrid Nanocomposite as a Potential New Biological Agent
Authors: Dulski, Mateusz
Malarz, Katarzyna
Kuczak, Michał
Dudek, Karolina
Matus, Krzysztof
Sułowicz, Sławomir
Mrozek-Wilczkiewicz, Anna
Nowak, Anna
Keywords: chemical reduction; silver-silica nanocomposite; carboxymethylcellulose; sodium alginate; physicochemical features; antimicrobial activity; anticancer activity; colon cancer; breast cancer; pancreatic cancer; glioblastoma
Issue Date: 2020
Citation: "Nanomaterials" (2020), iss. 10, art. no. 2551, s. 1-24
Abstract: To solve the problem of human diseases caused by a combination of genetic and environmental factors or by microorganisms, intense research to find completely new materials is required. One of the promising systems in this area is the silver-silica nanocomposites and their derivatives. Hence, silver and silver oxide nanoparticles that were homogeneously distributed within a silica carrier were fabricated. Their average size was d = (7.8 0.3) nm. The organic polymers (carboxymethylcellulose (CMC) and sodium alginate (AS)) were added to improve the biological features of the nanocomposite. The first system was prepared as a silver chlorine salt combination that was immersed on a silica carrier with coagulated particles whose size was d = (44.1 2.3) nm, which coexisted with metallic silver. The second system obtained was synergistically interacted metallic and oxidized silver nanoparticles that were distributed on a structurally defective silica network. Their average size was d = (6.6 0.7) nm. Physicochemical and biological experiments showed that the tiny silver nanoparticles in Ag/SiO2 and Ag/SiO2@AS inhibited E. coli, P. aeruginosa, S. aureus, and L. plantarum’s cell growth as well as caused a high anticancer e ect. On the other hand, the massive silver nanoparticles of Ag/SiO2@CMC had a weaker antimicrobial e ect, although they highly interacted against PANC-1. They also generated reactive oxygen species (ROS) as well as the induction of apoptosis via the p53-independent mechanism.
DOI: 10.3390/nano10122551
ISSN: 2079-4991
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