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http://hdl.handle.net/20.500.12128/193| Title: | Investigating biological activity spectrum for novel styrylquinazoline analogues |
| Authors: | Jampilek, J. Musioł, Robert Finster, Jacek Pesko, M. Carroll, J. Kralova, K. Vejsova, M. O'Mahony, J. Coffey, A. Dohnal, J. Polański, Jarosław |
| Keywords: | In vitro antifungal activity; In vitro antimycobacterial activity; Lipophilicity; PET inhibition; Spinach chloroplasts; Structure-activity relationships; Styrylquinazolinone and styrylquinazoline derivatives |
| Issue Date: | 2009 |
| Citation: | Molecules (Basel), vol. 14, iss. 10 (2009), s. 4246-4265 |
| Abstract: | In this study, series of ring-substituted 2-styrylquinazolin-4(3H)-one and 4-chloro-2-styrylquinazoline derivatives were prepared. The syntheses of the discussed compounds are presented. The compounds were analyzed by RP-HPLC to determine lipophilicity. They were tested for their inhibitory activity on photosynthetic electron transport (PET) in spinach (Spinacia oleracea L.) chloroplasts. Primary in vitro screening of the synthesized compounds was also performed against four mycobacterial strains and against eight fungal strains. Several compounds showed biological activity comparable with or higher than that of the standard isoniazid. It was found that the electronic properties of the R substituent, and not the total lipophilicity of the compound, were decisive for the photosynthesis-inhibiting activity of tested compounds. |
| URI: | http://hdl.handle.net/20.500.12128/193 |
| DOI: | 10.3390/molecules14104246 |
| ISSN: | 1420-3049 |
| Appears in Collections: | Artykuły (WNŚiT) |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Jampilek_Investigating_biological_activity_spectrum_for_novel_styrylquinazoline_analogues.pdf | 400,59 kB | Adobe PDF | View/Open |
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