Skip navigation

Please use this identifier to cite or link to this item:
Title: High-Pressure Dielectric Studies—a Way to Experimentally Determine the Solubility of a Drug in the Polymer Matrix at Low Temperatures
Authors: Chmiel, Krzysztof
Knapik-Kowalczuk, Justyna
Kamińska, Ewa
Tajber, Lidia
Paluch, Marian
Keywords: ASD; dielectric spectroscopy; solubility; high-pressure; nimesulide; Kollidon VA64; Flory−Huggins theory
Issue Date: 2021
Citation: "Molecular Pharmaceutics" (2021), Vol. 18, iss. 8, s. 3050–3062
Abstract: In this work, we employed broad-band dielectric spectroscopy to determine the solubility limits of nimesulide in the Kollidon VA64 matrix at ambient and elevated pressure conditions. Our studies confirmed that the solubility of the drug in the polymer matrix decreases with increasing pressure, and molecular dynamics controls the process of recrystallization of the excess of amorphous nimesulide from the supersaturated drug−polymer solution. More precisely, recrystallization initiated at a certain structural relaxation time of the sample stops when a molecular mobility different from the initial one is reached, regardless of the temperature and pressure conditions. Finally, based on the presented results, one can conclude that by transposing vertically the results obtained at elevated pressures, one can obtain the solubility limit values corresponding to low temperatures. This approach was validated by the comparison of the experimentally determined points with the theoretically obtained values based on the Flory−Huggins theory.
DOI: 10.1021/acs.molpharmaceut.1c00264
ISSN: 1543-8392
Appears in Collections:Artykuły (WNŚiT)

Files in This Item:
File Description SizeFormat 
Knapik_Kowalczuk_high_preassure_dielectric_studies.pdf6,27 MBAdobe PDFView/Open
Show full item record

Uznanie Autorstwa 3.0 Polska Creative Commons License Creative Commons