http://hdl.handle.net/20.500.12128/21069
Tytuł: | Photosynthesis-inhibiting activity of N-(Disubstitutedphenyl)-3- hydroxynaphthalene-2-carboxamides |
Autor: | Kos, Jiri Gonec, Tomas Oravec, Michal Jendrzejewska, Izabela Jampilek, Josef |
Słowa kluczowe: | hydroxynaphthalene-carboxamides; PET inhibition; spinach chloroplasts; structureactivity relationships |
Data wydania: | 2021 |
Źródło: | "Molecules" 2021, iss. 14, art. no. 4336 |
Abstrakt: | A set of twenty-four 3-hydroxynaphthalene-2-carboxanilides, disubstituted on the anilide ring by combinations of methoxy/methyl/fluoro/chloro/bromo and ditrifluoromethyl groups at different positions, was prepared. The compounds were tested for their ability to inhibit photosynthetic electron transport (PET) in spinach (Spinacia oleracea L.) chloroplasts. N-(3,5-Difluorophenyl)-, N-(3,5-dimethylphenyl)-, N-(2,5-difluorophenyl)- and N-(2,5-dimethylphenyl)-3-hydroxynaphthalene-2-carboxamides showed the highest PET-inhibiting activity (IC50 ~ 10 M) within the series. These compounds were able to inhibit PET in photosystem II. It has been found that PET-inhibiting activity strongly depends on the position of the individual substituents on the anilide ring and on the lipophilicity of the compounds. The electron-withdrawing properties of the substituents contribute towards the PET activity of these compounds. |
URI: | http://hdl.handle.net/20.500.12128/21069 |
DOI: | 10.3390/molecules26144336 |
ISSN: | 1420-3049 1431-5165 |
Pojawia się w kolekcji: | Artykuły (WNŚiT) |
Plik | Opis | Rozmiar | Format | |
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Kos_Photosynthesis_inhibiting_activity_of_N_(Disubstitutedphenyl)_3.pdf | 935,48 kB | Adobe PDF | Przejrzyj / Otwórz |
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