DC pole | Wartość | Język |
dc.contributor.author | Fus-Kujawa, Agnieszka | - |
dc.contributor.author | Sieroń, Łukasz | - |
dc.contributor.author | Dobrzyńska, Estera | - |
dc.contributor.author | Chajec, Łukasz | - |
dc.contributor.author | Mendrek, Barbara | - |
dc.contributor.author | Jarosz, Natalia | - |
dc.contributor.author | Głowacki, Łukasz | - |
dc.contributor.author | Dubaj, Kamila | - |
dc.contributor.author | Kowalczuk, Agnieszka | - |
dc.contributor.author | Bajdak-Rusinek, Karolina | - |
dc.date.accessioned | 2022-05-09T07:00:54Z | - |
dc.date.available | 2022-05-09T07:00:54Z | - |
dc.date.issued | 2022 | - |
dc.identifier.citation | "Biomolecules" (2022), Vol. 12, iss. 5, art. nr 608 | pl_PL |
dc.identifier.issn | 2218-273X | - |
dc.identifier.uri | http://hdl.handle.net/20.500.12128/23349 | - |
dc.description.abstract | Apoptosis is a widely controlled, programmed cell death, defects in which are the source of
various diseases such as neurodegenerative diseases as well as cancer. The use of apoptosis in the
therapy of various human diseases is of increasing interest, and the analysis of the factors involved in
its regulation is valuable in designing specific carriers capable of targeting cell death. Highly efficient
and precisely controlled delivery of genetic material by low-toxic carriers is one of the most important
challenges of apoptosis-based gene therapy. In this work, we investigate the effect of the star polymer
with 28 poly(N,N0-dimethylaminoethyl methacrylate) arms (STAR) on human cells, according to its
concentration and structure. We show that star polymer cytotoxicity increases within its concentration
and time of cells treatment. Except for cytotoxic effect, we observe morphological changes such as a
shrinkage, loss of shape and begin to detach. We also prove DNA condensation after star polymer
treatment, one of the most characteristic feature of apoptosis. The results indicate that the use of STAR
triggers apoptosis in cancer cells compared to various normal cells, what makes these nanoparticles
a promising drug in therapeutic strategy, which targets apoptosis. We demonstrate highlighting
potential of star polymers as an innovative tool for anti-cancer therapy. | pl_PL |
dc.language.iso | en | pl_PL |
dc.rights | Uznanie autorstwa 3.0 Polska | * |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/pl/ | * |
dc.subject | apoptosis | pl_PL |
dc.subject | star polymers vectors | pl_PL |
dc.subject | delivery systems | pl_PL |
dc.subject | cross-membrane transport | pl_PL |
dc.title | Star Polymers as Non-Viral Carriers for Apoptosis Induction | pl_PL |
dc.type | info:eu-repo/semantics/article | pl_PL |
dc.identifier.doi | 10.3390/biom12050608 | - |
Pojawia się w kolekcji: | Artykuły (WNP)
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