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dc.contributor.authorBorys, Przemysław-
dc.contributor.authorTrybek, Paulina-
dc.contributor.authorDworakowska, Beata-
dc.contributor.authorBednarczyk, Piotr-
dc.contributor.authorWawrzkiewicz-Jałowiecka, Agata-
dc.identifier.citation"Journal of Physical Chemistry B" (2022)pl_PL
dc.description.abstractThe patch-clamp technique is a powerful tool that allows for a long observation of transport protein activity in real time. Experimental traces of single-channel currents can be considered as a record of the channel’s conformational switching related to its activation and gating. In this work, we present a mathematically simple method of patch-clamp data analysis that assesses the connectivity and occupancy of distinct conformational substates of the channel. The proposed approach appears to be a big step forward due to its possible applications in the determination of channel substates related to disease and in the analysis of drug−channel interactions on the level of repetitive sequences of channel conformations. This is especially important in cases when molecular dynamics docking is impossible and Markovian modeling requires ambiguous optimization tasks.pl_PL
dc.rightsUznanie autorstwa 3.0 Polska*
dc.subjectCluster chemistrypl_PL
dc.subjectPlasma membranepl_PL
dc.titleNew Diagnostic Tool for Ion Channel Activity Hidden Behind the Dwell-Time Correlationspl_PL
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