DC pole | Wartość | Język |
dc.contributor.advisor | Kamiński, Kamil | - |
dc.contributor.advisor | Maksym, Paulina | - |
dc.contributor.author | Bernat, Roksana | - |
dc.date.accessioned | 2022-06-30T12:18:10Z | - |
dc.date.available | 2022-06-30T12:18:10Z | - |
dc.date.issued | 2022 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.12128/23582 | - |
dc.description | Praca zawiera artykuły w języku angielskim. | pl_PL |
dc.description.abstract | Presented PhD dissertation consisting of a series of four scientific papers aimed
to develop a unique synthetic strategy based on a dually-catalyzed approach combining
an ‘internal’ non-toxic (organo)catalyst and ‘external’ physical factor (elevated pressure),
inducing/controlling the course of the polymerization process of various types of monomers.
This work is mainly focused on the polymerization of monomers classified
as 'hardly-polymerizable' and ‘less activated', especially y-butyrolactone (GBL)
and l-vinyl-2-pyrrolidone (VP) - being precursors of particularly important polymers
intended for biomedical and pharmaceutical applications. The main goal of this work was
to develop innovative, highly efficient and controlled methods of polymerization
(GBL ring-opening polymerization (ROP) and VP free-radical polymerization (FRP)),
allowing to obtain ultra-pure polymers of well-defined parameters (i.e. tailored molecular
weight, dispersity and chain topology).
The conducted research confirmed that the use of high pressure can force GBL ROP
which is not possible at atmospheric pressure or proceeds with low efficiency,
even at extremely low temperatures. The application of elevated pressure also enabled FRP
of VP in a controlled manner yielding ultra-pure polymers of parameters currently
unattainable in the industry (moderate dispersity) by applying
a fast and efficient synthetic strategy without using any additional catalysts. The routine
analysis of the obtained macromolecules (NMR, FT-IR, SEC-LALLS, MALDI-TOF)
was extended to comprehensive, interdisciplinary research (including calorimetric,
rheological and biological studies). It was also investigated if the polymer structure (topology
and length of the PVP chains) affects both drug loading content and drug release profile
and it was assessed as a key factor in the development of new formulations with active
pharmaceutical ingredients.
To sum up, the results of the research discussed in this dissertation clearly
demonstrated that the use of system compression allows to i) overcome the thermodynamic
limitations of 'hardly-polymerizable' systems, ii) reduce the reaction time and significantly
increase the efficiency, Hi) produce of tailored polymers of better or even unique parameters
(higher molecular weight and smaller dispersity) in comparison to the polymerization
performer at ambient pressure, iv) simplify the reaction system and reduce/eliminate the
necessity of using toxic reagents. | pl_PL |
dc.language.iso | pl | pl_PL |
dc.publisher | Katowice : Uniwersytet Śląski | pl_PL |
dc.subject | polimeryzacja | pl_PL |
dc.subject | polimery w medycynie | pl_PL |
dc.subject | podwójna kataliza | pl_PL |
dc.subject | leki | pl_PL |
dc.title | Wysokociśnieniowa metodologia syntezy ultraczystych materiałów polimerowych do zastosowań biomedycznych i farmaceutycznych | pl_PL |
dc.type | info:eu-repo/semantics/doctoralThesis | pl_PL |
Pojawia się w kolekcji: | Rozprawy doktorskie (WNŚiT)
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