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Title: Organic micropollutants paracetamol and ibuprofen - toxicity, biodegradation, and genetic background of their utilization by bacteria
Authors: Żur, Joanna
Piński, Artur
Marchlewicz, Ariel
Hupert-Kocurek, Katarzyna
Wojcieszyńska, Danuta
Guzik, Urszula
Keywords: Biodegradation; Biotransformation; Gene clusters; Ibuprofen; Monocyclic NSAIDs; Paracetamol
Issue Date: 2018
Citation: Environmental Science and Pollution Research, vol. 25, iss. 22 (2018), s. 21498–21524
Abstract: Currently, analgesics and nonsteroidal anti-inflammatory drugs (NSAIDs) are classified as one of the most emerging group of xenobiotics and have been detected in various natural matrices. Among them, monocyclic paracetamol and ibuprofen, widely used to treat mild and moderate pain are the most popular. Since long-term adverse effects of these xenobiotics and their biological and pharmacokinetic activity especially at environmentally relevant concentrations are better understood, degradation of such contaminants has become a major concern. Moreover, to date, conventional wastewater treatment plants (WWTPs) are not fully adapted to remove that kind of micropollutants. Bioremediation processes, which utilize bacterial strains with increased degradation abilities, seem to be a promising alternative to the chemical methods used so far. Nevertheless, despite the wide prevalence of paracetamol and ibuprofen in the environment, toxicity and mechanism of their microbial degradation as well as genetic background of these processes remain not fully characterized. In this review, we described the current state of knowledge about toxicity and biodegradation mechanisms of paracetamol and ibuprofen and provided bioinformatics analysis concerning the genetic bases of these xenobiotics decomposition.
DOI: 10.1007/s11356-018-2517-x
ISSN: 0944-1344
Appears in Collections:Artykuły (WBiOŚ)

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