The pharmaceutical industry has been one of the most lucrative business areas of all
time. However, faced with numerous problems in recent years, it appears to be declining.
Despite the use of the latest technology, there has been no significant improvement which
would result in the implementation of new, better, and more innovative pharmaceuticals.
The aim of this study was to optimize the database exploration and analysis methods
in terms of determining trends in pharma R&D and to propose strategies to facilitate the process
of drug development. This study shows the synergy between the numerous research methods
in several scientific fields, such as chemistry, computer science, economics and pharmacy.
Thus, the calculated chemical descriptors and economic parameters were used in statistical
analysis. Moreover, comparative analysis of trends and developments, both in science and
the pharmaceutical industry, has been presented. Thus, an effort was made to explain the role
and impact of the market for the trends in pharma which could encourage changes in the drug
structure. A population of FDA drugs were collected, characterized by drug-like and drug-age
properties and additional implementation of the fragmentation algorithms helped to understand
the topology of the investigated drug population.
In summary, the analysis revealed many interesting trends in drug development in recent
years. The study shed new light on the known methods for the design of active compounds.