DC pole | Wartość | Język |
dc.contributor.author | Haznar-Garbacz, Dorota | - |
dc.contributor.author | Kamińska, Ewa | - |
dc.contributor.author | Żakowiecki, Daniel | - |
dc.contributor.author | Lachmann, Marek | - |
dc.contributor.author | Kamiński, Kamil | - |
dc.contributor.author | Garbacz, Grzegorz | - |
dc.contributor.author | Dorożyński, Przemysław | - |
dc.contributor.author | Kulinowski, Piotr | - |
dc.date.accessioned | 2019-03-27T09:37:06Z | - |
dc.date.available | 2019-03-27T09:37:06Z | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | AAPS PharmSciTech, Vol. 19, Issue 2 (2018), s. 951-960 | pl_PL |
dc.identifier.issn | 1530-9932 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.12128/8669 | - |
dc.description.abstract | The presented work describes the formulation and characterization of modified
release glassy solid dosage forms (GSDFs) containing an amorphous nifedipine, as a model
BCS (Biopharmaceutical Classification System) class II drug. The GSDFs were prepared by
melting nifedipine together with octaacetyl sucrose. Dissolution profiles, measured under
standard and biorelevant conditions, were compared to those obtained from commercially
available formulations containing nifedipine such as modified release (MR) tablets and
osmotic release oral system (OROS). The results indicate that the dissolution profiles of the
GSDFs with nifedipine are neither affected by the pH of the dissolution media, type and
concentration of surfactants, nor by simulated mechanical stress of biorelevant intensity.
Furthermore, it was found that the dissolution profiles of the novel dosage forms were similar
to the profiles obtained from the nifedipine OROS. The formulation of GSDFs is relatively
simple, and the dosage forms were found to have favorable dissolution characteristics. | pl_PL |
dc.language.iso | en | pl_PL |
dc.rights | Uznanie autorstwa 3.0 Polska | * |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/pl/ | * |
dc.subject | acetylated saccharides | pl_PL |
dc.subject | modified release | pl_PL |
dc.subject | sustained release | pl_PL |
dc.subject | amorphous drugs | pl_PL |
dc.subject | biorelevant dissolution stress test | pl_PL |
dc.subject | oral osmotic system | pl_PL |
dc.title | Melts of octaacetyl sucrose as oral-modified release dosage forms for delivery of poorly soluble compound in stable amorphous form | pl_PL |
dc.type | info:eu-repo/semantics/article | pl_PL |
dc.identifier.doi | 10.1208/s12249-017-0912-0 | - |
Pojawia się w kolekcji: | Artykuły (WNŚiT)
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