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Title: Effects of Polylactide Copolymer Implants and Platelet-Rich Plasma on Bone Regeneration within a Large Calvarial Defect in Sheep
Authors: Błaszczyk, Bartłomiej
Kaspera, Wojciech
Ficek, Krzysztof
Kajor, Maciej
Binkowski, Marcin
Stodolak-Zych, Ewa
Grajoszek, Aniela
Stojko, Jerzy
Bursig, Henryk
Ładziński, Piotr
Keywords: copolymer; bone regeneration
Issue Date: 2018
Citation: BioMed Research International, 2018, vol. 2018, art. no 4120471
Abstract: The aim of this study was to verify whether L-lactide/DL-lactide copolymer 80/20 (PLDLLA) and platelet-rich plasma (PRP) trigger bone formation within critical-sized calvarial defects in adult sheep (𝑛 = 6). Two craniectomies, each ca. 3 cm in diameter, were created in each animal. The first craniectomy was protected with an inner polylactide membrane, filled with PRP-polylactide granules, and covered with outer polylactide membrane. The second control craniectomy was left untreated. The animals were euthanized at 6, 7, 17, 19, 33, and 34 weeks after surgery, and the quality and the rate of reossification were assessed histomorphometrically and microtomographically.The study demonstrated that application of implantsmade of PLDLLA 80/20 combined with an osteopromotive substance (e.g., PRP) may promote bone healing in large calvarial defect in sheep. These promising proof-of-concept studies need to be verified in the future on a larger cohort of animals and over a longer period of time in order to draw definitive conclusions.
DOI: 10.1155/2018/4120471
ISSN: 2314-6133
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