Circadian rhythm of spontaneous non-linear peptidization with proteinogenic amino acids in abiotic solutions versus homochirality

Abstract

In this short communication, we report on three striking phenomena of the circadian rhythm. One was observed with the non-linear concentration changes of the monomeric L-Cys and the non-linear yields of the L-Cys derived peptides, when undergoing spontaneous non-linear peptidization. The other one was observed with the binary L-Phe-L-Pro system, and the third one with L-Ser, D-Ser, and DL-Ser. So far, no analogous reports have been released on the circadian rhythm of the spontaneous non-linear peptidization of proteinogenic amino acids in a sterile abiotic environment (70% aqueous acetonitrile, or 70% aqueous methanol solutions). At the moment, we cannot find any rational explanation of this phenomenon, yet it seems highly probable that its origin is analogous to or even of a primordial nature for the circadian rhythm phenomena abundantly found in biological samples by other researchers. An experimentally established lack of the circadian rhythm with peptidization of the non-proteinogenic amino acid (DSer) can encourage us to revisit a still unsolved question of homochirality preconditions.