Skip navigation

Please use this identifier to cite or link to this item:
Title: The role of oxidative stress in activity of anticancer thiosemicarbazones
Authors: Malarz, Katarzyna
Mrozek-Wilczkiewicz, Anna
Serda, Maciej
Rejmund, Marta
Polański, Jarosław
Musioł, Robert
Keywords: thiosemicarbazones; anticancer; iron chelators; reactive oxygen species; oxidative stress
Issue Date: 2018
Citation: Oncotarget, Vol. 9, no. 25 (2018), s. 17689-17710
Abstract: Thiosemicarbazones are chelators of transition metals such as iron or copper whose anticancer potency is intensively investigated. Although two compounds from this class have entered clinical trials, their precise mechanism of action is still unknown. Recent studies have suggested the mobilization of the iron ions from a cell, as well as the inhibition of ribonucleotide reductase, and the formation of reactive oxygen species. The complexity and vague nature of this mechanism not only impedes a more rational design of novel compounds, but also the further development of those that are highly active that are already in the preclinical phase. In the current work, a series of highly active thiosemicarbazones was studied for their antiproliferative activity in vitro. Our experiments indicate that these complexes have ionophoric properties and redox activity. They appeared to be very effective generating reactive oxygen species and deregulating the antioxidative potential of a cell. Moreover, the genes that are responsible for antioxidant capacity were considerably deregulated, which led to the induction of apoptosis and cell cycle arrest. On the other hand, good intercalating properties of the studied compounds may explain their ability to cleave DNA strands and to also poison related enzymes through the formation of reactive oxygen species. These findings may help to explain the particularly high selectivity that they have over normal cells, which generally have a stronger redox equilibrium.
DOI: 10.18632/oncotarget.24844
ISSN: 1949-2553
Appears in Collections:Artykuły (WNŚiT)

Files in This Item:
File Description SizeFormat 
Malarz_The_role_of_oxidative_stress.pdf4,41 MBAdobe PDFView/Open
Show full item record

Uznanie Autorstwa 3.0 Polska Creative Commons License Creative Commons