DC pole | Wartość | Język |
dc.contributor.author | Wojnar, Weronika | - |
dc.contributor.author | Zych, Maria | - |
dc.contributor.author | Borymski, Sławomir | - |
dc.contributor.author | Kaczmarczyk-Sedlak, Ilona | - |
dc.date.accessioned | 2020-02-28T12:44:13Z | - |
dc.date.available | 2020-02-28T12:44:13Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | Antioxidants, Vol. 9 (2020), Art. No. 160 | pl_PL |
dc.identifier.issn | 2076-3921 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.12128/12919 | - |
dc.description.abstract | Prolonged hyperglycemia is one of the main causes of reactive oxygen species and free
radicals generation in diabetes which may a ect various organs, including the eye. Oxidative damage
to proteins and lipids in the eye lens could lead to cataract formation. To cope with oxidative
stress, the endogenous antioxidative system may be supported by the supplementation of exogenous
antioxidants. The aim of this study was to evaluate the e ect of chrysin, a natural flavonoid,
on oxidative stress and polyol pathway-related markers in the lenses of streptozotocin-induced type
1 male diabetic rats. Chrysin at doses of 50 and 100 mg/kg was administered by gavage for 28 days.
This treatment resulted in a decrease in antioxidative enzymes activity and oxidative stress index.
Moreover, chrysin administration elevated the reduced glutathione level in the lenses. A decrease in
the markers linked to oxidative damage to proteins and lipids in the lenses was noted, especially after
treatment with 50 mg/kg of chrysin. Neither of the chrysin doses a ected glycemia-related markers in
the serum or altered parameters related to the polyol pathway and advanced glycation end-products
level in the lenses of diabetic rats. Upon obtaining results, it can be concluded that chrysin reveals
antioxidative activity in the lenses but shows no antihyperglycemic or antiglycation properties. | pl_PL |
dc.language.iso | en | pl_PL |
dc.rights | Uznanie autorstwa 3.0 Polska | * |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/pl/ | * |
dc.subject | type 1 diabetes | pl_PL |
dc.subject | chrysin | pl_PL |
dc.subject | lens | pl_PL |
dc.subject | rats | pl_PL |
dc.subject | oxidative stress | pl_PL |
dc.subject | oxidative damage | pl_PL |
dc.title | Chrysin Reduces Oxidative Stress but Does Not Affect Polyol Pathway in the Lenses of Type 1 Diabetic Rats | pl_PL |
dc.type | info:eu-repo/semantics/article | pl_PL |
dc.identifier.doi | 10.3390/antiox9020160 | - |
Pojawia się w kolekcji: | Artykuły (WNP)
|