DC pole | Wartość | Język |
dc.contributor.author | Kasperkiewicz, Katarzyna | - |
dc.contributor.author | Świerzko, Anna S. | - |
dc.contributor.author | Przybyła, Marta | - |
dc.contributor.author | Szemraj, Janusz | - |
dc.contributor.author | Barski, Jarosław | - |
dc.contributor.author | Skurnik, Mikael | - |
dc.contributor.author | Kałużyński, Andrzej | - |
dc.contributor.author | Cedzyński, Maciej | - |
dc.date.accessioned | 2020-12-10T14:00:14Z | - |
dc.date.available | 2020-12-10T14:00:14Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | "Journal of Immunology Research" (2020), art. no. 7439506, s. 1-12 | pl_PL |
dc.identifier.issn | 2314-7156 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.12128/17721 | - |
dc.description.abstract | Yersinia enterocolitica O:3 is mentioned among the most common arthritogenic pathogens. Bacterial components (including
lipopolysaccharide (LPS)) may persist in the joint after eradication of infection. Having an adjuvant activity, LPS may enhance
production of anticollagen antibodies, involved in the pathogenesis of rheumatoid arthritis. Furthermore, its ability to activate
complement contributes to the inflammation. The aim of this work was to investigate whether Yersinia LPS (coinjected with
collagen) is associated with arthritis progression or other pathological effects and to elucidate the mechanism of this association.
It was demonstrated that murine mannose-binding lectin C (MBL-C) recognizes the inner core heptoses of the Rd1 chemotype
LPS of Yersinia. In addition, the Rd1 LPS activates the MBL-associated serine protease 1 (MASP-1) stronger than the S and Ra
chemotype LPS and comparable to Klebsiella pneumoniae O:3 LPS. However, in contrast to the latter, Yersinia Rd1 LPS was
associated neither with the adjuvancity nor with the enhancement of pathological changes in animal paws/impairment of
motility. On the other hand, it seemed to be more hepatotoxic when compared with the other tested endotoxins, while the
enlargement of inguinal lymph nodes and drop in hepatic MBL-C expression (at the mRNA level) were independent of LPS
chemotype. Our data did not suggest no greater impact Y. enterocolitica O:3 on the development or severity of arthropathy
related to anticollagen antibody-induced arthritis in mice, although its interaction with MBL-C and subsequent complement
activation may contribute to some adverse effects. | pl_PL |
dc.language.iso | en | pl_PL |
dc.rights | Uznanie autorstwa 3.0 Polska | * |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/pl/ | * |
dc.subject | Yersinia enterocolitica | pl_PL |
dc.subject | lipopolysaccharide | pl_PL |
dc.title | The role of Yersinia enterocolitica O:3 lipopolysaccharide in collageninduced arthritis | pl_PL |
dc.type | info:eu-repo/semantics/article | pl_PL |
dc.identifier.doi | 10.1155/2020/7439506 | - |
Pojawia się w kolekcji: | Artykuły (WNP)
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