DC pole | Wartość | Język |
dc.contributor.author | Metryka, Oliwia | - |
dc.contributor.author | Wasilkowski, Daniel | - |
dc.contributor.author | Mrozik, Agnieszka | - |
dc.date.accessioned | 2021-11-18T13:02:14Z | - |
dc.date.available | 2021-11-18T13:02:14Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | "International Journal of the Molecular Sciences" (2021), iss. 21, art. no. 11811, s. 1-22 | pl_PL |
dc.identifier.issn | 1422-0067 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.12128/21897 | - |
dc.description.abstract | The antimicrobial activity of nanoparticles (NPs) is a desirable feature of various products
but can become problematic when NPs are released into different ecosystems, potentially endangering
living microorganisms. Although there is an abundance of advanced studies on the toxicity and
biological activity of NPs on microorganisms, the information regarding their detailed interactions
with microbial cells and the induction of oxidative stress remains incomplete. Therefore, this work
aimed to develop accurate oxidation stress profiles of Escherichia coli, Bacillus cereus and Staphylococcus
epidermidis strains treated with commercial Ag-NPs, Cu-NPs, ZnO-NPs and TiO2-NPs. The methodology
used included the following determinations: toxicological parameters, reactive oxygen species
(ROS), antioxidant enzymes and dehydrogenases, reduced glutathione, oxidatively modified proteins
and lipid peroxidation. The toxicological studies revealed that E. coli was most sensitive to NPs than
B. cereus and S. epidermidis. Moreover, NPs induced the generation of specific ROS in bacterial cells,
causing an increase in their concentration, which further resulted in alterations in the activity of the
antioxidant defence system and protein oxidation. Significant changes in dehydrogenases activity
and elevated lipid peroxidation indicated a negative effect of NPs on bacterial outer layers and
respiratory activity. In general, NPs were characterised by very specific nano-bio effects, depending
on their physicochemical properties and the species of microorganism. | pl_PL |
dc.language.iso | en | pl_PL |
dc.rights | Uznanie autorstwa 3.0 Polska | * |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/pl/ | * |
dc.subject | bacteria | pl_PL |
dc.subject | nanoparticles | pl_PL |
dc.subject | toxicological parameters | pl_PL |
dc.subject | reactive oxygen species | pl_PL |
dc.subject | antioxidant enzymes | pl_PL |
dc.subject | protein and lipid oxidation | pl_PL |
dc.title | Insight into the antibacterial activity of selected metal nanoparticles and alterations within the antioxidant defence system in Escherichia coli, Bacillus cereus and Staphylococcus epidermidis | pl_PL |
dc.type | info:eu-repo/semantics/article | pl_PL |
dc.identifier.doi | 10.3390/ijms222111811 | - |
Pojawia się w kolekcji: | Artykuły (WNP)
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