DC pole | Wartość | Język |
dc.contributor.author | Albertyńska, Marta | - |
dc.contributor.author | Okła, Hubert | - |
dc.contributor.author | Jasik, Krzysztof | - |
dc.contributor.author | Urbańska-Jasik, Danuta | - |
dc.contributor.author | Pol, Przemysław | - |
dc.date.accessioned | 2021-12-14T14:09:47Z | - |
dc.date.available | 2021-12-14T14:09:47Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | "Scientific Reports" (2021), Vol. 11, art. no. 23663, s. 1-10 | pl_PL |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.12128/22107 | - |
dc.description.abstract | Babesiosis is one of the most common infections in free-living animals and is rapidly becoming
significant among human zoonoses. Cases of acute renal failure in humans caused by Babesia spp.
have been described in the literature. The kidneys are characterised by intense blood flow through
the blood vessels, which increases the likelihood of contact with the intra-erythrocyte parasite. The
aim of this study was to observe the influence of B. microti (ATCC 30221) on renal epithelial cells
in vitro cultured (NRK-52E line) and Wistar rats’ kidney. Both NRK-52E cells and rats’ kidney sections
were analysed by light microscopy, transmission electron microscopy (TEM) and fluorescence in situ
hybridization (FISH). Necrotic changes in renal epithelial cells have been observed in vitro and in vivo.
In many cross-sections through the rats’ kidney, adhesion of blood cells to the vascular endothelium,
accumulation of erythrocytes and emboli were demonstrated. In NRK-52E culture, elements with a
distinctly doubled cell membrane resembling B. microti were found inside the cytoplasm and adjacent
to the cell layer. The study indicates a chemotactic tendency for B. microti to adhere to the renal
tubules’ epithelium, a possibility of piroplasms entering the renal epithelial cells, their proliferation
within the cytoplasm and emboli formation. | pl_PL |
dc.language.iso | en | pl_PL |
dc.rights | Uznanie autorstwa 3.0 Polska | * |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/pl/ | * |
dc.subject | parasitology | pl_PL |
dc.subject | mechanisms of disase | pl_PL |
dc.subject | Babesia | pl_PL |
dc.title | Interactions between Babesia microti merozoites and rat kidney cells in a short-term in vitro culture and animal model | pl_PL |
dc.type | info:eu-repo/semantics/article | pl_PL |
dc.identifier.doi | 10.1038/s41598-021-03079-0 | - |
Pojawia się w kolekcji: | Artykuły (WNP)
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