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dc.contributor.authorFrancikowski, Jacek-
dc.contributor.authorBaran, Bartosz-
dc.contributor.authorPłachetka-Bożek, Anna-
dc.contributor.authorKrzyżowski, Michał-
dc.contributor.authorAugustyniak, Maria-
dc.identifier.citationOpen Life Science, Vol. 1, iss. 1 (2016), s. 244-249pl_PL
dc.description.abstractIn this study, we aimed to evaluate whether exposure to caffeine in the early stages of development affect AdoR mRNA expression levels in the fruit fly (Drosophila melanogaster) and how this will relate to the developmental success of flies. Adenosine receptors are seen as the most important biochemical targets of caffeine. Simultaneously adenosine signaling orchestrates the development and growth of insects. We demonstrate that AdoR mRNA expression in D. melanogaster is persistent from early stages till imago. Strong alterations in AdoR expression were observed in larvae that had been treated with caffeine. However, after the imaginal molt, the differences in AdoR expression between the insects from all of the test groups evened out despite a wide range of developmental success in the groups. Taken together, these results suggest that caffeine affects the expression of its cellular targets even from the early stages of fruit fly development and thus there is a significantly lower larvae-to-adult survival rate. Moreover, we also proved that the expression of AdoR undergoes a peculiar reset during the maturation of D. melanogaster despite the conditions in which larvae developed.pl_PL
dc.rightsUznanie autorstwa-Użycie niekomercyjne-Bez utworów zależnych 3.0 Polska*
dc.subjectAdenosine receptorpl_PL
dc.subjectDrosophila melanogasterpl_PL
dc.subjectInsect developmentpl_PL
dc.titleCaffeine effects on AdoR mRNA expression in Drosophila melanogasterpl_PL
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Uznanie autorstwa - użycie niekomercyjne, bez utworów zależnych 3.0 Polska Creative Commons License Creative Commons