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Title: Enzymes involved in naproxen degradation by Planococcus sp. S5
Authors: Wojcieszyńska, Danuta
Domaradzka, Dorota
Hupert-Kocurek, Katarzyna
Guzik, Urszula
Keywords: Planococcus; biodegradation; naproxen; enzymes induction; aromatic plant compounds
Issue Date: 2016
Citation: Polish Journal of Microbiology, 2016, no. 2, s. 177-182
Abstract: Naproxen is a one of the most popular non-steroidal anti-inflammatory drugs (NSAIDs) entering the environment as a result of high consumption. For this reason, there is an emerging need to recognize mechanisms of its degradation and enzymes engaged in this process. Planococcus sp. S5 is a gram positive strain able to degrade naproxen in monosubstrate culture (27%). However, naproxen is not a sufficient growth substrate for this strain. In the presence of benzoate, 4-hydroxybenzoic acid, 3,4-dihydroxybenzoic acid or vanillic acid as growth substrates, the degradation of 21.5%, 71.71%, 14.75% and 8.16% of naproxen was observed respectively. It was shown that the activity of monooxygenase, hydroxyquinol 1,2-dioxygenase, protocatechuate 3,4-dioxygenase and protocatechuate 4,5-dioxyegnase in strain S5 was induced after growth of the strain with naproxen and 4-hydroxybenzoate. Moreover, in the presence of naproxen activity of gentisate 1,2-dioxygenase, enzyme engaged in 4-hydroxybenzoate metabolism, was completely inhibited. The obtained results suggest that monooxygenase and hydroxyquinol 1,2-dioxygenase are the main enzymes in naproxen degradation by Planococcus sp. S5.
DOI: 10.5604/17331331.1204477
ISSN: 1733-1331
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