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Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12128/9055
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dc.contributor.authorHoma, Joanna-
dc.contributor.authorStalmach, Monika-
dc.contributor.authorWilczek, Grażyna-
dc.contributor.authorKołaczkowska, Elżbieta-
dc.date.accessioned2019-05-08T10:07:05Z-
dc.date.available2019-05-08T10:07:05Z-
dc.date.issued2016-
dc.identifier.citationJournal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology, Vol. 186, iss. 4 (2016), s. 417-430pl_PL
dc.identifier.issn0174-1578-
dc.identifier.urihttp://hdl.handle.net/20.500.12128/9055-
dc.description.abstractOxidative stress is harmful to the microbes but also to the host, and may result in bystander damage or death. Because of this, respiratory burst triggered in phagocytes by pathogens is counteracted by production of antioxidative factors. The aim of this work was to examine effectiveness of the latter system in earthworms Eisenia andrei by induction of reactive oxygen species, lipofuscin and phenoloxidase by natural (LPS, zymosan, Micrococus luteus) and synthetic (phorbol ester, PMA) stimulants. The compounds impaired numbers, viability (increased apoptosis) and composition of coelomocytes, and triggered the antioxidant activity of catalase and selenium-dependent glutathione peroxidase. The natural pathogenic compounds, unlike PMA, strongly activated antioxidative responses that diminished cell apoptosis. Moreover, repeated exposure to the same or different pathogenic compounds did not induce respiratory burst exhausted phenotype showing that coelomocytes are constantly at bay to withstand numerous infections. The current study reveals importance and efficiency of the oxidative–antioxidative systems in annelids but also confirms its evolutionary conservatism and complexity even in lower taxa of the animal kingdom.pl_PL
dc.language.isoenpl_PL
dc.rightsUznanie autorstwa 3.0 Polska*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/pl/*
dc.subjectPMApl_PL
dc.subjectLPSpl_PL
dc.subjectZymosanpl_PL
dc.subjectMicrococus luteuspl_PL
dc.subjectApoptosispl_PL
dc.subjectAntioxidative enzymespl_PL
dc.titleEffective activation of antioxidant system by immune-relevant factors reversely correlates with apoptosis of Eisenia andrei coelomocytespl_PL
dc.typeinfo:eu-repo/semantics/articlepl_PL
dc.identifier.doi10.1007/s00360-016-0973-5-
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