http://hdl.handle.net/20.500.12128/9137
Tytuł: | Biodegradation and biotransformation of polycyclic non-steroidal anti-inflammatory drugs |
Autor: | Domaradzka, Dorota Guzik, Urszula Wojcieszyńska, Danuta |
Słowa kluczowe: | biodegradation; biotransformation; non-steroidal anti-inflammatory drugs; microorganisms |
Data wydania: | 2015 |
Źródło: | Reviews in Environmental Science and Biotechnology, Vol. 14, iss. 2 (2015), s. 229-239 |
Abstrakt: | In recent years the increased use of polycyclic non-steroidal anti-inflammatory drugs has resulted in their presence in the environment. This in turn may cause potential negative effects on living organisms. While the biotransformation mechanisms of polycyclic non-steroidal anti-inflammatory drugs in the human body and in other mammals have been extensively studied, degradation of these drugs by microorganisms has seldom been investigated and is largely unknown. Biotransformation/biodegradation of polycyclic non-steroidal anti-inflammatory drugs is caused by fungal microorganisms, mainly white-rot fungi, and a few strains of bacteria. However, hitherto only complete degradation of olsazine was described. The first step of the transformation is most often hydroxylation catalyzed by cytochrom P-450 monooxygenases, or oxygenation by laccases and three peroxidases: lignin peroxidase, manganese-dependent peroxidase and versatile peroxidase manganese-dependent peroxidase. The aim of this work is to summarize the knowledge about the biotransformation and/or biodegradation of polycyclic non-steroidal anti-inflammatory drugs and to present their biotransformation pathways. |
URI: | http://hdl.handle.net/20.500.12128/9137 |
DOI: | 10.1007/s11157-015-9364-8 |
ISSN: | 1569-1705 |
Pojawia się w kolekcji: | Artykuły (WNP) |
Plik | Opis | Rozmiar | Format | |
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Domaradzka_Biodegradation_and_biotransformation.pdf | 601,69 kB | Adobe PDF | Przejrzyj / Otwórz |
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