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Title: Biodegradation and biotransformation of polycyclic non-steroidal anti-inflammatory drugs
Authors: Domaradzka, Dorota
Guzik, Urszula
Wojcieszyńska, Danuta
Keywords: biodegradation; biotransformation; non-steroidal anti-inflammatory drugs; microorganisms
Issue Date: 2015
Citation: Reviews in Environmental Science and Biotechnology, Vol. 14, iss. 2 (2015), s. 229-239
Abstract: In recent years the increased use of polycyclic non-steroidal anti-inflammatory drugs has resulted in their presence in the environment. This in turn may cause potential negative effects on living organisms. While the biotransformation mechanisms of polycyclic non-steroidal anti-inflammatory drugs in the human body and in other mammals have been extensively studied, degradation of these drugs by microorganisms has seldom been investigated and is largely unknown. Biotransformation/biodegradation of polycyclic non-steroidal anti-inflammatory drugs is caused by fungal microorganisms, mainly white-rot fungi, and a few strains of bacteria. However, hitherto only complete degradation of olsazine was described. The first step of the transformation is most often hydroxylation catalyzed by cytochrom P-450 monooxygenases, or oxygenation by laccases and three peroxidases: lignin peroxidase, manganese-dependent peroxidase and versatile peroxidase manganese-dependent peroxidase. The aim of this work is to summarize the knowledge about the biotransformation and/or biodegradation of polycyclic non-steroidal anti-inflammatory drugs and to present their biotransformation pathways.
DOI: 10.1007/s11157-015-9364-8
ISSN: 1569-1705
Appears in Collections:Artykuły (WBiOŚ)

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