DC pole | Wartość | Język |
dc.contributor.author | Abendrot, Michał | - |
dc.contributor.author | Chęcińska, Lilianna | - |
dc.contributor.author | Kusz, Joachim | - |
dc.contributor.author | Lisowska, Katarzyna | - |
dc.contributor.author | Zawadzka, Katarzyna | - |
dc.contributor.author | Felczak, Aleksandra | - |
dc.contributor.author | Kalinowska‐Lis, Urszula | - |
dc.date.accessioned | 2020-02-24T09:36:20Z | - |
dc.date.available | 2020-02-24T09:36:20Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | Molecules, Vol. 25 (2020), Art. No. 951 | pl_PL |
dc.identifier.issn | 1420-3049 | - |
dc.identifier.issn | 1420-3049 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.12128/12731 | - |
dc.description.abstract | The multifunctional profile of Zn2+ has influenced its great popularity in various
pharmaceutical, food, and cosmetic products. Despite the use of different inorganic and organic
zinc derivatives, the search for new zinc‐containing compounds with a safer skin profile still
remains an open issue. The present paper describes the synthesis, structural characterization, and
antibacterial activity of zinc(II) complexes with proteinogenic amino acids as potential candidates
for dermatological treatments. The obtained complexes are of the general formula [Zn(AA)2],
where AA represents an amino acid (L‐Glu, Gly, L‐His, L‐Pro, L‐Met, and L‐Trp). Their synthesis
was designed in such a way that the final bis(aminoacidate) zinc(II) complexes did not contain any
counter‐ions such as Cl−, NO3−, or SO42− that can cause some skin irritations. The chemical structure
and composition of the compounds were identified by 1H NMR spectroscopy and elemental
analysis, and four were also characterized by single‐crystal X‐ray diffraction. The Hirshfeld surface
analysis for the Zn2+ metallic center helped to determine its coordination number and geometry for
each complex. Finally, the antibacterial properties of the complexes were determined with respect
to three Gram‐positive strains, viz. Staphylococcus aureus ATCC 6538, Staphylococcus epidermidis
ATCC 12228, and Streptococcus pyogenes ATCC 19615, and two Gram‐negative bacteria, viz.
Escherichia coli ATCC 25992 and Pseudomonas aeruginosa ATCC 27853, and were compared with the
activity of zinc 2‐pirrolidone 5‐carboxylate (ZnPCA), commonly applied in dermatology. It was
found that the Zn(II) complexes with methionine and glycine exhibited a higher antibacterial
activity than the tested standard, and the antimicrobial properties of complex with Trp were
satisfactory. The results of the antimicrobial activity examination allow us to postulate that the
obtained zinc complexes might become new active substances for use in dermatological products. | pl_PL |
dc.language.iso | en | pl_PL |
dc.rights | Uznanie autorstwa 3.0 Polska | * |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/pl/ | * |
dc.subject | zinc(II) complexes | pl_PL |
dc.subject | proteinogenic amino acids | pl_PL |
dc.subject | crystal structures | pl_PL |
dc.subject | antibacterial activity | pl_PL |
dc.subject | Hirshfeld surface analysis | pl_PL |
dc.title | Zinc(II) Complexes with Amino Acids for Potential Use in Dermatology: Synthesis, Crystal Structures, and Antibacterial Activity | pl_PL |
dc.type | info:eu-repo/semantics/article | pl_PL |
dc.identifier.doi | 10.3390/molecules25040951 | - |
Pojawia się w kolekcji: | Artykuły (WNŚiT)
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