DC pole | Wartość | Język |
dc.contributor.author | Knapik-Kowalczuk, Justyna | - |
dc.contributor.author | Kramarczyk, Daniel | - |
dc.contributor.author | Chmiel, Krzysztof | - |
dc.contributor.author | Romanova, Jana | - |
dc.contributor.author | Kawakami, Kohsaku | - |
dc.contributor.author | Paluch, Marian | - |
dc.date.accessioned | 2020-04-23T10:25:42Z | - |
dc.date.available | 2020-04-23T10:25:42Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | "Pharmaceutics" Vol. 12, iss. 4 (2020), art. no 384 | pl_PL |
dc.identifier.issn | 1999-4923 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.12128/13624 | - |
dc.description.abstract | In this paper, the role of mesoporous silica (MS) particle size in the stabilization of
amorphous simvastatin (SVT) is revealed. For inhibiting recrystallization of the supercooled drug,
the two MS materials (Syloid® XDP 3050 and Syloid® 244 FP) were employed. The crystallization
tendency of SVT alone and in mixture with the MS materials was investigated by Differential
Scanning Calorimetry (DSC) and Broadband Dielectric Spectroscopy (BDS). Neither confinement of
the SVT molecules inside the MS pores nor molecular interactions between functional groups of the
SVT molecules and the surface of the stabilizing excipient could explain the observed stabilization
effect. The stabilization effect might be correlated with diffusion length of the SVT molecules in the
MS materials that depended on the particle size. Moreover, MS materials possessing different
particle sizes could offer free spaces with different sizes, which might influence crystal growth of
SVT. All of these factors must be considered when mesoporous materials are used for stabilizing
pharmaceutical glasses. | pl_PL |
dc.language.iso | en | pl_PL |
dc.rights | Uznanie autorstwa 3.0 Polska | * |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/pl/ | * |
dc.subject | Simvastatin | pl_PL |
dc.subject | amorphous pharmaceuticals | pl_PL |
dc.subject | mesoporous silica | pl_PL |
dc.subject | stabilization | pl_PL |
dc.subject | recrystallization | pl_PL |
dc.title | Importance of Mesoporous Silica Particle Size in the Stabilization of Amorphous Pharmaceuticals - The Case of Simvastatin | pl_PL |
dc.type | info:eu-repo/semantics/article | pl_PL |
dc.identifier.doi | 10.3390/pharmaceutics12040384 | - |
Pojawia się w kolekcji: | Artykuły (WNŚiT)
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