DC pole | Wartość | Język |
dc.contributor.author | Szafraniec-Szczęsny, Joanna | - |
dc.contributor.author | Antosik-Rogóż, Agata | - |
dc.contributor.author | Knapik-Kowalczuk, Justyna | - |
dc.contributor.author | Kurek, Mateusz | - |
dc.contributor.author | Szefer, Ewa | - |
dc.contributor.author | Gawlak, Karolina | - |
dc.contributor.author | Chmiel, Krzysztof | - |
dc.contributor.author | Peralta, Sebastian | - |
dc.contributor.author | Niwiński, Krzysztof | - |
dc.contributor.author | Pielichowski, Krzysztof | - |
dc.contributor.author | Paluch, Marian | - |
dc.contributor.author | Jachowicz, Renata | - |
dc.date.accessioned | 2020-05-19T07:27:06Z | - |
dc.date.available | 2020-05-19T07:27:06Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | Pharmaceutics, Vol. 12, iss 5 (2020), art. no 438 | pl_PL |
dc.identifier.issn | 1999-4923 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.12128/14092 | - |
dc.description.abstract | The formation of solid dispersions with the amorphous drug dispersed in the polymeric
matrix improves the dissolution characteristics of poorly soluble drugs. Although they provide an
improved absorption after oral administration, the recrystallization, which can occur upon
absorption of moisture or during solidification and other formulation stages, serves as a major
challenge. This work aims at understanding the amorphization-recrystallization changes of
bicalutamide. Amorphous solid dispersions with poly(vinylpyrrolidone-co-vinyl acetate) (PVP/VA)
were obtained by either ball milling or spray drying. The applied processes led to drug
amorphization as confirmed using X-ray diffraction and differential scanning calorimetry. Due to a
high propensity towards mechanical activation, the changes of the crystal structure of physical
blends of active pharmaceutical ingredient (API) and polymer upon pressure were also examined.
The compression led to drug amorphization or transition from form I to form II polymorph,
depending on the composition and applied force. The formation of hydrogen bonds confirmed
using infrared spectroscopy and high miscibility of drug and polymer determined using nonisothermal
dielectric measurements contributed to the high stability of amorphous solid
dispersions. They exhibited improved wettability and dissolution enhanced by 2.5- to 11-fold in
comparison with the crystalline drug. The drug remained amorphous upon compression when the
content of PVP/VA in solid dispersions exceeded 20% or 33%, in the case of spray-dried and milled
systems, respectively. | pl_PL |
dc.language.iso | en | pl_PL |
dc.rights | Uznanie autorstwa 3.0 Polska | * |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/pl/ | * |
dc.subject | amorphous solid dispersions | pl_PL |
dc.subject | physical stability | pl_PL |
dc.subject | bicalutamide | pl_PL |
dc.subject | Kollidon®VA64 | pl_PL |
dc.subject | dissolution | pl_PL |
dc.subject | compression | pl_PL |
dc.title | Compression-Induced Phase Transitions of Bicalutamide | pl_PL |
dc.type | info:eu-repo/semantics/article | pl_PL |
dc.relation.journal | Pharmaceutics | pl_PL |
dc.identifier.doi | 10.3390/pharmaceutics12050438 | - |
Pojawia się w kolekcji: | Artykuły (WNŚiT)
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