DC pole | Wartość | Język |
dc.contributor.author | Zander, Thomas | - |
dc.contributor.author | Garamus, Vasil M. | - |
dc.contributor.author | Dédinaité, Andra | - |
dc.contributor.author | Claesson, Per M. | - |
dc.contributor.author | Bełdowski, Piotr | - |
dc.contributor.author | Górny, Krzysztof | - |
dc.contributor.author | Dendzik, Zbigniew | - |
dc.contributor.author | Wieland, D. C. Florian | - |
dc.contributor.author | Willumeit-Römer, Regine | - |
dc.date.accessioned | 2020-09-02T11:50:57Z | - |
dc.date.available | 2020-09-02T11:50:57Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | "Molecules (Basel)" Vol. 25, iss. 17 (2020), art. no. 3907 | pl_PL |
dc.identifier.issn | 1420-3049 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.12128/15819 | - |
dc.description.abstract | Hyaluronan is an essential physiological bio macromolecule with di erent functions.
One prominent area is the synovial fluid which exhibits remarkable lubrication properties. However,
the synovial fluid is a multi-component system where di erent macromolecules interact in a synergetic
fashion. Within this study we focus on the interaction of hyaluronan and phospholipids, which are
thought to play a key role for lubrication. We investigate how the interactions and the association
structures formed by hyaluronan (HA) and 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC)
are influenced by the molecular weight of the bio polymer and the ionic composition of the solution.
We combine techniques allowing us to investigate the phase behavior of lipids (di erential scanning
calorimetry, zeta potential and electrophoretic mobility) with structural investigation (dynamic light
scattering, small angle scattering) and theoretical simulations (molecular dynamics). The interaction
of hyaluronan and phospholipids depends on the molecular weight, where hyaluronan with lower
molecular weight has the strongest interaction. Furthermore, the interaction is increased by the
presence of calcium ions. Our simulations show that calcium ions are located close to the carboxylate
groups of HA and, by this, reduce the number of formed hydrogen bonds between HA and DPPC.
The observed change in the DPPC phase behavior can be attributed to a local charge inversion
by calcium ions binding to the carboxylate groups as the binding distribution of hyaluronan and
1,2-dipalmitoyl-sn-glycero-3-phosphocholine is not changed. | pl_PL |
dc.language.iso | en | pl_PL |
dc.rights | Uznanie autorstwa 3.0 Polska | * |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/pl/ | * |
dc.subject | phospholipid | pl_PL |
dc.subject | hyaluronan | pl_PL |
dc.subject | molecular interaction | pl_PL |
dc.subject | phase behavior | pl_PL |
dc.subject | binding distribution | pl_PL |
dc.title | Influence of the molecular weight and the presence of calcium ions on the molecular interaction of hyaluronan and DPPC | pl_PL |
dc.type | info:eu-repo/semantics/article | pl_PL |
dc.identifier.doi | 10.3390/molecules25173907 | - |
Pojawia się w kolekcji: | Artykuły (WNŚiT)
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