DC pole | Wartość | Język |
dc.contributor.author | Wawrzkiewicz-Jałowiecka, Agata | - |
dc.contributor.author | Trybek, Paulina | - |
dc.contributor.author | Borys, Przemysław | - |
dc.contributor.author | Dworakowska, Beata | - |
dc.contributor.author | Machura, Łukasz | - |
dc.contributor.author | Bednarczyk, Piotr | - |
dc.date.accessioned | 2020-10-19T07:27:42Z | - |
dc.date.available | 2020-10-19T07:27:42Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | "Cells" Vol. 9, iss. 10 (2020), art. no. 2305 | pl_PL |
dc.identifier.issn | 2073-4409 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.12128/16534 | - |
dc.description.abstract | The large-conductance voltage- and Ca2+-activated K+ channels (BK) are encoded in
humans by the Kcnma1 gene. Nevertheless, BK channel isoforms in different locations can exhibit
functional heterogeneity mainly due to the alternative splicing during the Kcnma1 gene transcription.
Here, we would like to examine the existence of dynamic diversity of BK channels from the inner
mitochondrial and cellular membrane from human glioblastoma (U-87 MG). Not only the standard
characteristics of the spontaneous switching between the functional states of the channel is discussed,
but we put a special emphasis on the presence and strength of correlations within the signal
describing the single-channel activity. The considered short- and long-range memory effects are here
analyzed as they can be interpreted in terms of the complexity of the switching mechanism between
stable conformational states of the channel. We calculate the dependencies of mean dwell-times
of (conducting/non-conducting) states on the duration of the previous state, Hurst exponents by
the rescaled range R/S method and detrended fluctuation analysis (DFA), and use the multifractal
extension of the DFA (MFDFA) for the series describing single-channel activity. The obtained results
unraveled statistically significant diversity in gating machinery between the mitochondrial and
cellular BK channels. | pl_PL |
dc.language.iso | en | pl_PL |
dc.rights | Uznanie autorstwa 3.0 Polska | * |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/pl/ | * |
dc.subject | glioblastoma | pl_PL |
dc.subject | BK channels in plasma membrane | pl_PL |
dc.subject | mitochondrial BK (mitoBK) channels | pl_PL |
dc.subject | patch-clamp | pl_PL |
dc.subject | hurst exponent | pl_PL |
dc.subject | detrended fluctuation analysis (DFA) | pl_PL |
dc.subject | multifractal detrended fluctuation analysis (MFDFA) | pl_PL |
dc.subject | Ca2+-sensitivity | pl_PL |
dc.title | Differences in gating dynamics of BK channels in cellular and mitochondrial membranes from human glioblastoma cells unraveled by short- and long-range correlations analysis | pl_PL |
dc.type | info:eu-repo/semantics/article | pl_PL |
dc.identifier.doi | 10.3390/cells9102305 | - |
Pojawia się w kolekcji: | Artykuły (WNŚiT)
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