DC pole | Wartość | Język |
dc.contributor.author | Jamróz, Witold | - |
dc.contributor.author | Knapik-Kowalczuk, Justyna | - |
dc.contributor.author | Szafraniec-Szczęsny, Joanna | - |
dc.contributor.author | Jurkiewicz, Karolina | - |
dc.contributor.author | Leszczyński, Bartosz | - |
dc.contributor.author | Paluch, Marian | - |
dc.contributor.author | Pyteraf, Jolanta | - |
dc.contributor.author | Kurek, Mateusz | - |
dc.contributor.author | Wróbel, Andrzej | - |
dc.contributor.author | Jachowicz, Renata | - |
dc.date.accessioned | 2020-11-12T09:47:35Z | - |
dc.date.available | 2020-11-12T09:47:35Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | "Materials" (2020), iss. 21, art. no. 4961, s. 1-20 | pl_PL |
dc.identifier.issn | 1996-1944 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.12128/16996 | - |
dc.description.abstract | The simplicity of object shape and composition modification make additive manufacturing
a great option for customized dosage form production. To achieve this goal, the correlation between
structural and functional attributes of the printed objects needs to be analyzed. So far, it has not
been deeply investigated in 3D printing-related papers. The aim of our study was to modify the
functionalities of printed tablets containing liquid crystal-forming drug itraconazole by introducing
polyvinylpyrrolidone-based polymers into the filament-forming matrices composed predominantly
of poly(vinyl alcohol). The e ect of the molecular reorganization of the drug and improved tablets’
disintegration was analyzed in terms of itraconazole dissolution. Micro-computed tomography was
applied to analyze how the design of a printed object (in this case, a degree of an infill) a ects its
reproducibility during printing. It was also used to analyze the structure of the printed dosage forms.
The results indicated that the improved disintegration obtained due to the use of Kollidon®CL-M
was more beneficial for the dissolution of itraconazole than the molecular rearrangement and liquid
crystal phase transitions. The lower infill density favored faster dissolution of the drug from printed
tablets. However, it negatively a ected the reproducibility of the 3D printed object. | pl_PL |
dc.language.iso | en | pl_PL |
dc.rights | Uznanie autorstwa 3.0 Polska | * |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/pl/ | * |
dc.subject | 3D printing | pl_PL |
dc.subject | fused deposition modeling | pl_PL |
dc.subject | hot-melt extrusion | pl_PL |
dc.subject | solid dosage forms | pl_PL |
dc.subject | itraconazole | pl_PL |
dc.title | Multivariate design of 3D printed immediate-release tablets with liquid crystal-forming drug - itraconazole | pl_PL |
dc.type | info:eu-repo/semantics/article | pl_PL |
dc.identifier.doi | 10.3390/ma13214961 | - |
Pojawia się w kolekcji: | Artykuły (WNŚiT)
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