Influence of selected auxiliary substances on some physicochemical properties of solid dispersions containing magnesium salts

Abstract

In this survey magnesium salrn in the form of solid dispersions were studied to examine the interaction of the drug and lecithin or Betain L-7, The results of thermal analysis of solid dispersions containing magnesium adipate Mg[Adip] anJ compounds of this salt with glycine substituent. and the partition coeffident (logP) of this saits applied for solid dispcrsion, have been presented in this paper. Lecithin (45% phosphatidykholine) or Tego" Betain L-7 (30% solution of amide betaine) have been added to magnesium salts to obtain a solid dispersion. The influence of auxiliary substances: Tego" Betain L-7 and lecithin on physicochemkal propcrties of the examined preparations has been assessed. The results of thermal anaiysis ( DT A, DSC, TG) of rnagnesium com pl ex es indicatetl their good thermal res i stance up to the tem,lerature of 375 K.