DC pole | Wartość | Język |
dc.contributor.author | Stryjska, Karolina | - |
dc.contributor.author | Korona-Glowniak, Izabela | - |
dc.contributor.author | Chęcińska, Lilianna | - |
dc.contributor.author | Kusz, Joachim | - |
dc.contributor.author | Ochocki, Justyn | - |
dc.date.accessioned | 2021-02-04T13:53:51Z | - |
dc.date.available | 2021-02-04T13:53:51Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | "International Journal of Molecular Science" (2021), iss. 4, art. no. 1510, s. 1-18 | pl_PL |
dc.identifier.issn | 1422-0067 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.12128/18831 | - |
dc.description.abstract | In a previous article, we reported on the higher toxicity of silver(I) complexes of miconazole
[Ag(MCZ)2NO3 (1)] and [Ag(MCZ)2ClO4 (2)] in HepG2 tumor cells compared to the corresponding
salts of silver, miconazole and cisplatin. Here, we present the synthesis of two silver(I)
complexes of miconazole containing two new counter ions in the form of Ag(MCZ)2X (MCZ =
1-[2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole]; X = BF4− (3), SbF6− (4)).
The novel silver(I) complexes were characterized by elemental analysis, 1H NMR, 13C NMR and
infrared (IR) spectroscopy, electrospray ionization (ESI)-MS spectrometry and
X-ray-crystallography. In the present study, the antimicrobial activity of all obtained silver(I)
complexes of miconazole against six strains of Gram-positive bacteria, five strains of
Gram-negative bacteria and yeasts was evaluated. The results were compared with those of a silver
sulfadiazine drug, the corresponding silver salts and the free ligand. Silver(I) complexes exhibited
significant activity against Gram-positive bacteria, which was much better than that of silver sulfadiazine
and silver salts. The highest antimicrobial activity was observed for the complex containing
the nitrate counter ion. All Ag(I) complexes of miconazole resulted in much better inhibition
of yeast growth than silver sulfadiazine, silver salts and miconazole. Moreover, the synthesized
silver(I) complexes showed good or moderate activity against Gram-negative bacteria compared
to the free ligand. | pl_PL |
dc.language.iso | en | pl_PL |
dc.rights | Uznanie autorstwa 3.0 Polska | * |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/pl/ | * |
dc.subject | synthesis | pl_PL |
dc.subject | silver(I) complexes | pl_PL |
dc.subject | NMR spectroscopy | pl_PL |
dc.subject | IR spectroscopy | pl_PL |
dc.subject | X-ray crystallography | pl_PL |
dc.subject | antimicrobial activity | pl_PL |
dc.title | Synthesis, spectroscopy, single-crystal structure analysis and antibacterial activity of two novel complexes of silver(I) with miconazole drug | pl_PL |
dc.identifier.doi | 10.3390/ijms22041510 | - |
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