DC pole | Wartość | Język |
dc.contributor.author | Jendrzejewska, Izabela | - |
dc.contributor.author | Goryczka, Tomasz | - |
dc.contributor.author | Pietrasik, Ewa | - |
dc.contributor.author | Klimontko, Joanna | - |
dc.contributor.author | Jampilek, Josef | - |
dc.date.accessioned | 2021-03-17T09:10:33Z | - |
dc.date.available | 2021-03-17T09:10:33Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | Molecules, 2020, iss. 24, art. no. 5909, s. 1-24 | pl_PL |
dc.identifier.issn | 1420-3049 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.12128/19538 | - |
dc.description.abstract | Studies carried out by X-ray and thermal analysis confirmed that acetaminophen
(paracetamol), declared by the manufacturers as an Active Pharmaceutical Ingredient (API),
was present in all studied medicinal drugs. Positions of diffraction lines (2θ angles) of the studied
drugs were consistent with standards for acetaminophen, available in the ICDD PDF database Release
2008.ID2θI values were lower than 0.2°, confirming the authenticity of the studied drugs. Also,
the values of interplanar distances dhkl for the examined samples were consistent with those present
in the ICDD. Presence of acetaminophen crystalising in the monoclinic system (form I) was confirmed.
Various line intensities for API were observed in the obtained diffraction patterns, indicating presence
of the preferred orientation of the crystallites in the examined samples. Thermal analysis of the studied
substances confirmed the results obtained by X-ray analysis. Drugs containing only acetaminophen
as an API have melting point close to that of pure acetaminophen. It was found that presence of other
active and auxiliary substances affected the shapes and positions of endothermal peaks significantly.
A broadening of endothermal peaks and their shift towards lower temperatures were observed
accompanying an increase in the contents of additional substances being “impurities” in relation to
the API. The results obtained by a combination of the two methods, X-ray powder diffraction (XRPD)
and differential scanning calorimetry/thermogravimetry (DSC/TGA), may be useful in determination
of abnormalities which can occur in pharmaceutical preparations, e.g., for distinguishing original
drugs and forged products, detection of the presence of a proper polymorphic form or too low content
of the active substance in the investigated drug. | pl_PL |
dc.language.iso | en | pl_PL |
dc.rights | Uznanie autorstwa 3.0 Polska | * |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/pl/ | * |
dc.subject | paracetamol | pl_PL |
dc.subject | drugs | pl_PL |
dc.subject | X-ray diffraction | pl_PL |
dc.subject | phase analysis | pl_PL |
dc.subject | thermal analysis | pl_PL |
dc.title | X-ray and thermal analysis of selected drugs containing acetaminophen | pl_PL |
dc.type | info:eu-repo/semantics/article | pl_PL |
dc.relation.journal | Molecules | pl_PL |
dc.identifier.doi | 10.3390/molecules25245909 | - |
Pojawia się w kolekcji: | Artykuły (WNŚiT)
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