http://hdl.handle.net/20.500.12128/19620
Tytuł: | Amino- and polyaminophthalazin-1(2H)-ones : synthesis, coordination properties, and biological activity |
Autor: | Malinowski, Zbigniew Fornal, Emilia Sumara, Agata Kontek, Renata Bukowski, Karol Pasternak, Beata Sroczyński, Dariusz Kusz, Joachim Małecka, Magdalena Nowak, Monika |
Słowa kluczowe: | amination; complexes; cytotoxicity; Pd cross-coupling; phthalazinone |
Data wydania: | 2021 |
Źródło: | Beilstein Journal of Organic Chemistry, Vol. 17 (2021), s. 558-568 |
Abstrakt: | Amino- and polyaminophthalazinones were synthesized by the palladium‐catalyzed amination (alkyl- and arylamines, polyamines) of 4-bromophthalazinones in good yields. The coordinating properties of selected aminophthalazinones towards Cu(II) ions were investigated and the participation of the nitrogen atoms in the complexation of the metal ion was shown. A biological screening of the potential cytotoxicity of selected synthesized compounds on HT-29 and PC-3 cell lines, as well as on the L-929 cell line, proved that some amino derivatives of phthalazinone show interesting anticancer activities. The detailed synthesis, spectroscopic data, and biological assays are reported. |
URI: | http://hdl.handle.net/20.500.12128/19620 |
DOI: | 10.3762/bjoc.17.50 |
ISSN: | 1860-5397 |
Pojawia się w kolekcji: | Artykuły (WNŚiT) |
Plik | Opis | Rozmiar | Format | |
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Malinowski_Amino_and_polyaminophthalazin_1_2H_ones.pdf | 1,62 MB | Adobe PDF | Przejrzyj / Otwórz |
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