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Zastosuj identyfikator do podlinkowania lub zacytowania tej pozycji: http://hdl.handle.net/20.500.12128/197
Tytuł: Ring-substituted 4-hydroxy-1H-quinolin-2-ones : preparation and biological activity
Autor: Jampilek, Josef
Musioł, Robert
Pesko, Matus
Kralova, Katarina
Vejsova, Marcela
Carroll, James
Coffey, Aidan
Finster, Jacek
Tabak, Dominik
Niedbała, Halina
Kozik, Violetta
Polański, Jarosław
Csollei, Jozef
Dohnal, Jiri
Słowa kluczowe: In vitro antifungal activity; Lipophilicity; OER inhibition; Quinolinone derivatives; Spinach chloroplasts; Structure-activity relationships
Data wydania: 2009
Źródło: Molecules (Basel), vol. 14, iss. 3 (2009), s. 1145-1159
Abstrakt: In the study, a series of twelve ring-substituted 4-hydroxy-1H-quinolin-2- one derivatives were prepared. The procedures for synthesis of the compounds are presented. The compounds were analyzed using RP-HPLC to determine lipophilicity and tested for their photosynthesis-inhibiting activity using spinach (Spinacia oleracea L.) chloroplasts. All the synthesized compounds were also evaluated for antifungal activity using in vitro screening with eight fungal strains. For all the compounds, the relationships between the lipophilicity and the chemical structure of the studied compounds are discussed, as well as their structure-activity relationships (SAR).
URI: http://hdl.handle.net/20.500.12128/197
DOI: 10.3390/molecules14031145
ISSN: 1420-3049
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