DC pole | Wartość | Język |
dc.contributor.author | Pałasz, Artur | - |
dc.contributor.author | Suszka-Świtek, Aleksandra | - |
dc.contributor.author | Francikowski, Jacek | - |
dc.contributor.author | Krzystanek, Marek | - |
dc.contributor.author | Bogus, Katarzyna | - |
dc.contributor.author | Skałbania, Jakub | - |
dc.contributor.author | Worthington, John J. | - |
dc.contributor.author | Mrzyk, Inga | - |
dc.date.accessioned | 2021-03-31T07:17:33Z | - |
dc.date.available | 2021-03-31T07:17:33Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | "Pharmaceuticals" (2021), iss. 4, art. no. 298, s. 1-8 | pl_PL |
dc.identifier.issn | 1424-8247 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.12128/19752 | - |
dc.description.abstract | Draxin belongs to the family of inhibitory axon-guiding factors that regulate neuronal
migration and axonal spreading in the developing brain. This glycoprotein has recently been considered
to play an important role both in hippocampal differentiation and adult neurogenesis in the
dentate gyrus. Given that it has been reported that antipsychotic drugs may affect neurite growth and
neurogenesis, we have therefore investigated whether chronic treatment with olanzapine modulates
draxin immunoreactivity in the adult rat hippocampus. After analysis of local fluorescence intensity,
we found a significant increase of draxin immunoexpression both in the subgranular zone (SGZ) and
granular zone of the rat hippocampus following long-term olanzapine administration. This study
reveals, for the first time, the modulatory effect of the atypical antipsychotic medication olanzapine
on expression of the novel chemorepulsive protein draxin in the context of adult neurogenesis regulation.
Moreover, this is the first report dealing with pharmacological aspects of draxin signaling. An
elevated draxin expression may indirectly support a recently formulated hypothesis that olanzapine
may drive adult neurogenesis via paracrine draxin-related signaling. This action of draxin is a
new element in the neurogenesis mechanism that may be part of the action of second-generation
antipsychotics in the treatment of schizophrenia, indicating more detailed molecular studies are
urgently required to fully investigate these potential novel mechanisms of neurogenesis. | pl_PL |
dc.language.iso | en | pl_PL |
dc.rights | Uznanie autorstwa 3.0 Polska | * |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/pl/ | * |
dc.subject | olanzapine | pl_PL |
dc.subject | draxin | pl_PL |
dc.subject | hippocampus | pl_PL |
dc.subject | adult neurogenesis | pl_PL |
dc.title | Olanzapine increases neural chemorepulsant-draxin expression in the adult rat hippocampus | pl_PL |
dc.type | info:eu-repo/semantics/article | pl_PL |
dc.identifier.doi | 10.3390/ph14040298 | - |
Pojawia się w kolekcji: | Artykuły (WNP)
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