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Title: How to obtain the maximum properties flexibility of 3d printed ketoprofen tablets using only one drug-loaded filament?
Authors: Pyteraf, Jolanta
Jamróz, Witold
Kurek, Mateusz
Szafraniec-Szczęsny, Joanna
Kramarczyk, Daniel
Jurkiewicz, Karolina
Knapik-Kowalczuk, Justyna
Tarasiuk, Jacek
Wroński, Sebastian
Paluch, Marian
Jachowicz, Renata
Keywords: 3D printing; fused deposition modeling; hot-melt extrusion; solid dosage forms; immediaterelease; sustained-release; ketoprofen
Issue Date: 2021
Citation: "Molecules (Basel)" 2021, iss. 11, art. no. 3106
Abstract: The flexibility of dose and dosage forms makes 3D printing a very interesting tool for personalized medicine, with fused deposition modeling being the most promising and intensively developed method. In our research, we analyzed how various types of disintegrants and drug loading in poly(vinyl alcohol)-based filaments affect their mechanical properties and printability. We also assessed the effect of drug dosage and tablet spatial structure on the dissolution profiles. Given that the development of a method that allows the production of dosage forms with different properties from a single drug-loaded filament is desirable, we developed a method of printing ketoprofen tablets with different dose and dissolution profiles from a single feedstock filament. We optimized the filament preparation by hot-melt extrusion and characterized them. Then, we printed single, bi-, and tri-layer tablets varying with dose, infill density, internal structure, and composition. We analyzed the reproducibility of a spatial structure, phase, and degree of molecular order of ketoprofen in the tablets, and the dissolution profiles. We have printed tablets with immediateand sustained-release characteristics using one drug-loaded filament, which demonstrates that a single filament can serve as a versatile source for the manufacturing of tablets exhibiting various release characteristics.
DOI: 10.3390/molecules26113106
ISSN: 1420-3049
Appears in Collections:Artykuły (WNŚiT)

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