DC pole | Wartość | Język |
dc.contributor.author | Knapik-Kowalczuk, Justyna | - |
dc.contributor.author | Kramarczyk, Daniel | - |
dc.contributor.author | Jurkiewicz, Karolina | - |
dc.contributor.author | Chmiel, Krzysztof | - |
dc.contributor.author | Paluch, Marian | - |
dc.date.accessioned | 2021-08-25T10:35:50Z | - |
dc.date.available | 2021-08-25T10:35:50Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | "Molecular Pharmaceutics" (2021), iss. 0, s. 1-13 | pl_PL |
dc.identifier.issn | 1543-8392 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.12128/21157 | - |
dc.description.abstract | In this study, the phase diagram of the ternary system of
ezetimibe−simvastatin−fenofibrate was established. It has been proven
that the ternary composition recommended for the treatment of mixed
hyperlipidemia forms a eutectic system. Since eutectic mixtures are
characterized by greater solubility and dissolution rate, the obtained result
can explain the marvelous medical effectiveness of combined therapy.
Considering that another well-known method for improving the aqueous
solubility is amorphization, the ternary system with eutectic concentration
was converted into an amorphous form. Thermal properties, molecular
dynamics, and physical stability of the obtained amorphous system were
thoroughly investigated through various experimental techniques compared
to both: neat amorphous active pharmaceutical ingredients
(considered separately) and other representative concentrations of ternary
mixture. The obtained results open up a new way of selecting the therapeutic concentrations for combined therapies, a path that
considers one additional variable: eutecticity. | pl_PL |
dc.language.iso | en | pl_PL |
dc.rights | Uznanie autorstwa 3.0 Polska | * |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/pl/ | * |
dc.subject | amorphous pharmaceuticals | pl_PL |
dc.subject | physical stability | pl_PL |
dc.subject | ternary eutectic | pl_PL |
dc.subject | eutectic system | pl_PL |
dc.subject | ezetimibe | pl_PL |
dc.subject | simvastatin | pl_PL |
dc.subject | fenofibrate | pl_PL |
dc.title | Ternary eutectic ezetimibe-simvastatin-fenofibrate system and the physical stability of Its amorphous form | pl_PL |
dc.type | info:eu-repo/semantics/article | pl_PL |
dc.identifier.doi | 10.1021/acs.molpharmaceut.1c00485 | - |
Pojawia się w kolekcji: | Artykuły (WNŚiT)
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