DC pole | Wartość | Język |
dc.contributor.author | Palion-Gazda, Joanna | - |
dc.contributor.author | Luz, André | - |
dc.contributor.author | Raposo, Luis R. | - |
dc.contributor.author | Choroba, Katarzyna | - |
dc.contributor.author | Nycz, Jacek E. | - |
dc.contributor.author | Bieńko, Alina | - |
dc.contributor.author | Lewińska, Agnieszka | - |
dc.contributor.author | Erfurt, Karol | - |
dc.contributor.author | Babtista, Pedro V. | - |
dc.contributor.author | Machura, Barbara | - |
dc.contributor.author | Fernandes, Alexandra R. | - |
dc.contributor.author | Shul’pina, Lidia | - |
dc.contributor.author | Ikonniko, Nikolai S. | - |
dc.contributor.author | Shul’pin, Georgiy B. | - |
dc.date.accessioned | 2021-10-25T07:23:14Z | - |
dc.date.available | 2021-10-25T07:23:14Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | "Molecules" (2021), iss. 21, art. no. 6364, s. 1-23 | pl_PL |
dc.identifier.issn | 1420-3049 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.12128/21824 | - |
dc.description.abstract | Methyl-substituted 8-hydroxyquinolines (Hquin) were successfully used to synthetize
five-coordinated oxovanadium(IV) complexes: [VO(2,6-(Me)2-quin)2] (1), [VO(2,5-(Me)2-quin)2] (2)
and [VO(2-Me-quin)2] (3). Complexes 1–3 demonstrated high catalytic activity in the oxidation of
hydrocarbons with H2O2 in acetonitrile at 50 C, in the presence of 2-pyrazinecarboxylic acid (PCA)
as a cocatalyst. The maximum yield of cyclohexane oxidation products attained was 48%, which is
high in the case of the oxidation of saturated hydrocarbons. The reaction leads to the formation of a
mixture of cyclohexyl hydroperoxide, cyclohexanol and cyclohexanone. When triphenylphosphine is
added, cyclohexyl hydroperoxide is completely converted to cyclohexanol. Consideration of the regioand
bond-selectivity in the oxidation of n-heptane and methylcyclohexane, respectively, indicates
that the oxidation proceeds with the participation of free hydroxyl radicals. The complexes show
moderate activity in the oxidation of alcohols. Complexes 1 and 2 reduce the viability of colorectal
(HCT116) and ovarian (A2780) carcinoma cell lines and of normal dermal fibroblasts without showing
a specific selectivity for cancer cell lines. Complex 3 on the other hand, shows a higher cytotoxicity in
a colorectal carcinoma cell line (HCT116), a lower cytotoxicity towards normal dermal fibroblasts
and no effect in an ovarian carcinoma cell line (order of magnitude HCT116 > fibroblasts > A2780). | pl_PL |
dc.language.iso | en | pl_PL |
dc.rights | Uznanie autorstwa 3.0 Polska | * |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/pl/ | * |
dc.subject | vanadium(IV) complexes | pl_PL |
dc.subject | biological activity | pl_PL |
dc.subject | catalytic properties | pl_PL |
dc.subject | 8-hydroxyquinoline | pl_PL |
dc.subject | cytotoxicity studies | pl_PL |
dc.title | Vanadium(IV) complexes with methyl-substituted 8-hydroxyquinolines : catalytic potential in the oxidation of hydrocarbons and alcohols with peroxides and biological activity | pl_PL |
dc.type | info:eu-repo/semantics/article | pl_PL |
dc.identifier.doi | 10.3390/molecules26216364 | - |
Pojawia się w kolekcji: | Artykuły (WNŚiT)
|