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dc.contributor.authorPalion-Gazda, Joanna-
dc.contributor.authorLuz, André-
dc.contributor.authorRaposo, Luis R.-
dc.contributor.authorChoroba, Katarzyna-
dc.contributor.authorNycz, Jacek E.-
dc.contributor.authorBieńko, Alina-
dc.contributor.authorLewińska, Agnieszka-
dc.contributor.authorErfurt, Karol-
dc.contributor.authorBabtista, Pedro V.-
dc.contributor.authorMachura, Barbara-
dc.contributor.authorFernandes, Alexandra R.-
dc.contributor.authorShul’pina, Lidia-
dc.contributor.authorIkonniko, Nikolai S.-
dc.contributor.authorShul’pin, Georgiy B.-
dc.identifier.citation"Molecules" (2021), iss. 21, art. no. 6364, s. 1-23pl_PL
dc.description.abstractMethyl-substituted 8-hydroxyquinolines (Hquin) were successfully used to synthetize five-coordinated oxovanadium(IV) complexes: [VO(2,6-(Me)2-quin)2] (1), [VO(2,5-(Me)2-quin)2] (2) and [VO(2-Me-quin)2] (3). Complexes 1–3 demonstrated high catalytic activity in the oxidation of hydrocarbons with H2O2 in acetonitrile at 50 C, in the presence of 2-pyrazinecarboxylic acid (PCA) as a cocatalyst. The maximum yield of cyclohexane oxidation products attained was 48%, which is high in the case of the oxidation of saturated hydrocarbons. The reaction leads to the formation of a mixture of cyclohexyl hydroperoxide, cyclohexanol and cyclohexanone. When triphenylphosphine is added, cyclohexyl hydroperoxide is completely converted to cyclohexanol. Consideration of the regioand bond-selectivity in the oxidation of n-heptane and methylcyclohexane, respectively, indicates that the oxidation proceeds with the participation of free hydroxyl radicals. The complexes show moderate activity in the oxidation of alcohols. Complexes 1 and 2 reduce the viability of colorectal (HCT116) and ovarian (A2780) carcinoma cell lines and of normal dermal fibroblasts without showing a specific selectivity for cancer cell lines. Complex 3 on the other hand, shows a higher cytotoxicity in a colorectal carcinoma cell line (HCT116), a lower cytotoxicity towards normal dermal fibroblasts and no effect in an ovarian carcinoma cell line (order of magnitude HCT116 > fibroblasts > A2780).pl_PL
dc.rightsUznanie autorstwa 3.0 Polska*
dc.subjectvanadium(IV) complexespl_PL
dc.subjectbiological activitypl_PL
dc.subjectcatalytic propertiespl_PL
dc.subjectcytotoxicity studiespl_PL
dc.titleVanadium(IV) complexes with methyl-substituted 8-hydroxyquinolines : catalytic potential in the oxidation of hydrocarbons and alcohols with peroxides and biological activitypl_PL
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