DC pole | Wartość | Język |
dc.contributor.author | Koperwas, Kajetan | - |
dc.contributor.author | Tu, Wenkang | - |
dc.contributor.author | Affouard, Frédéric | - |
dc.contributor.author | Adrjanowicz, Karolina | - |
dc.contributor.author | Kaśkorz, Filip | - |
dc.contributor.author | Paluch, Marian | - |
dc.date.accessioned | 2021-11-03T13:54:24Z | - |
dc.date.available | 2021-11-03T13:54:24Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | "Crystal Growth and Design" (2021), no. 0, s. 1-12 | pl_PL |
dc.identifier.issn | 1528-7505 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.12128/21858 | - |
dc.description.abstract | This paper examines the pressure effect on the
crystallization rate of the pharmaceutically active enantiomerically
pure S-enantiomer and the racemic mixture of the well-known drug
ibuprofen. Performed experimental studies revealed that at ambient
pressure S-ibuprofen crystallizes faster than the racemic mixture.
When the pressure increases, the crystallization rate slows down for
both systems, but interestingly it is more apparent in the case of the
S-enantiomer. It is found that this experimentally observed trend
can be understood based on the predictions of the classical
nucleation theory. We suggest that the solid−liquid interfacial free
energy is the main reason for the observed variations in S- and RS-ibuprofen’s stability behaviors. Employing a special method of
computational studies, i.e., the capillary fluctuation method, we show that the increase in pressure affects the solid−liquid interfacial
free energy for S- and RS-ibuprofen in an entirely different way. Importantly, the detected differences correspond to the
experimentally observed variations in the overall crystallization rates. | pl_PL |
dc.language.iso | en | pl_PL |
dc.rights | Uznanie autorstwa 3.0 Polska | * |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/pl/ | * |
dc.subject | Interfaces | pl_PL |
dc.subject | Crystallization | pl_PL |
dc.subject | Liquids | pl_PL |
dc.subject | Insulators | pl_PL |
dc.subject | Nucleation | pl_PL |
dc.subject | Ibuprom | pl_PL |
dc.subject | S-Enantiomer | pl_PL |
dc.title | Pressure dependence of the crystallization rate for the S-enantiomer and a racemic mixture of ibuprofen | pl_PL |
dc.type | info:eu-repo/semantics/article | pl_PL |
dc.identifier.doi | 10.1021/acs.cgd.1c00980 | - |
Pojawia się w kolekcji: | Artykuły (WNŚiT)
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