DC pole | Wartość | Język |
dc.contributor.author | Milecka, Aldona | - |
dc.contributor.author | Chmiel, Krzysztof | - |
dc.contributor.author | Jurkiewicz, Karolina | - |
dc.contributor.author | Hachuła, Barbara | - |
dc.contributor.author | Łunio, Rafał | - |
dc.contributor.author | Żakowiecki, Daniel | - |
dc.contributor.author | Hyla, Kinga | - |
dc.contributor.author | Milanowski, Bartłomiej | - |
dc.contributor.author | Koperwas, Kajetan | - |
dc.contributor.author | Kamiński, Kamil | - |
dc.contributor.author | Paluch, Marian | - |
dc.contributor.author | Kamińska, Ewa | - |
dc.date.accessioned | 2021-12-10T15:03:28Z | - |
dc.date.available | 2021-12-10T15:03:28Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | "Molecular Pharmaceutics" (2021), iss. 0, s. 1-11 | pl_PL |
dc.identifier.issn | 1543-8392 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.12128/22078 | - |
dc.description.abstract | In this paper, several experimental techniques [X-ray diffraction,
differential scanning calorimetry (DSC), thermogravimetry, Fourier transform infrared
spectroscopy, and broad-band dielectric spectroscopy] have been applied to
characterize the structural and thermal properties, H-bonding pattern, and molecular
dynamics of amorphous bosentan (BOS) obtained by vitrification and cryomilling of
the monohydrate crystalline form of this drug. Samples prepared by these two methods
were found to be similar with regard to their internal structure, H-bonding scheme, and
structural (α) dynamics in the supercooled liquid state. However, based on the analysis
of α-relaxation times (dielectric measurements) predicted for temperatures below the
glass-transition temperature (Tg), as well as DSC thermograms, it was concluded that
the cryoground sample is more aged (and probably more physically stable) compared
to the vitrified one. Interestingly, such differences in physical properties turned out to
be reflected in the lower intrinsic dissolution rate of BOS obtained by cryomilling (in
the first 15 min of dissolution test) in comparison to the vitrified drug. Furthermore, we showed that cryogrinding of the crystalline
BOS monohydrate leads to the formation of a nearly anhydrous amorphous sample. This finding, different from that reported by
Megarry et al. [Carbohydr. Res. 2011, 346, 1061−1064] for trehalose (TRE), was revealed on the basis of infrared and thermal
measurements. Finally, two various hypotheses explaining water removal upon cryomilling have been discussed in the manuscript. | pl_PL |
dc.language.iso | en | pl_PL |
dc.rights | Uznanie autorstwa 3.0 Polska | * |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/pl/ | * |
dc.subject | bosentan | pl_PL |
dc.subject | vitrification | pl_PL |
dc.subject | cryomilling | pl_PL |
dc.subject | molecular mobility | pl_PL |
dc.subject | water removal | pl_PL |
dc.subject | dissolution rate | pl_PL |
dc.title | Studies on the vitrified and cryomilled bosentan | pl_PL |
dc.type | info:eu-repo/semantics/article | pl_PL |
dc.identifier.doi | 10.1021/acs.molpharmaceut.1c00613 | - |
Pojawia się w kolekcji: | Artykuły (WNŚiT)
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