DC pole | Wartość | Język |
dc.contributor.author | Stygar, Dominika | - |
dc.contributor.author | Sawczyn, Tomasz | - |
dc.contributor.author | Skrzep-Poloczek, Bronisława | - |
dc.contributor.author | Karcz-Socha, Iwona | - |
dc.contributor.author | Doleżych, Bogdan | - |
dc.contributor.author | Zawisza-Raszka, Agnieszka | - |
dc.contributor.author | Augustyniak, Maria | - |
dc.contributor.author | Żwirska-Korczala, Krystyna | - |
dc.contributor.author | Karcz, Wojciech Konrad | - |
dc.date.accessioned | 2017-11-10T22:31:46Z | - |
dc.date.available | 2017-11-10T22:31:46Z | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | Open Life Sciences, Vol. 10, iss. 1 (2015), s. 278-284 | pl_PL |
dc.identifier.issn | 2391-5412 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.12128/221 | - |
dc.description.abstract | Objective: Ileal transposition procedure (IT), in combination with sleeve gastrectomy, is widely used to induce diabetes remission and to control related metabolic abnormalities. A transposition of a long segment of distal ileum in obese Zucker rats improved glucose tolerance 6 months after IT. The premise of our study was to to examine the long - term effects of ileum transposition on the liver glycolytic enzymes content in a euglycemic group of operated Zucker rats. Methods: Twenty male Zucker rats underwent either the transposition of 50% distal ileum or a sham surgery. Six months after surgery, liver tissue concentrations of glycogen synthase kinase alpha (GSK-3α), glucose 6-phosphatase (G6PC), glycogen phosphorylase (PYGM) and phosphofructokinase (PFK) and HSP70 were assessed by immunoenzymatic methods. Results: HSP70 values were significantly higher in the IT group compared to SHAM. G6PC liver concentrations in the IT group were almost 1.45-fold lower than in the SHAM operated rats. Statistical analyses (F-test) showed HSP70 levels were significantly related to caveolin-1and SHAM group. Conclusions: Lowered glycolytic enzyme concentrations assessed in the liver suggest positive effects on glucose metabolism in long-term observations. | pl_PL |
dc.language.iso | en | pl_PL |
dc.rights | Uznanie autorstwa-Użycie niekomercyjne-Bez utworów zależnych 3.0 Polska | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/pl/ | * |
dc.subject | HSP70 | pl_PL |
dc.subject | Ileal transposition | pl_PL |
dc.subject | Metabolic surgery | pl_PL |
dc.subject | Obesity surgery | pl_PL |
dc.subject | Type 2 diabetes mellitus | pl_PL |
dc.title | Ileal transposition in rats influenced glucose metabolism and HSP70 levels | pl_PL |
dc.type | info:eu-repo/semantics/article | pl_PL |
dc.identifier.doi | 10.1515/biol-2015-0029 | - |
Pojawia się w kolekcji: | Artykuły (WNP)
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