DC pole | Wartość | Język |
dc.contributor.author | Serda, Maciej | - |
dc.contributor.author | Gawecki, Robert | - |
dc.contributor.author | Dulski, Mateusz | - |
dc.contributor.author | Sajewicz, Mieczysław | - |
dc.contributor.author | Talik, Ewa | - |
dc.contributor.author | Szubka, Magdalena | - |
dc.contributor.author | Zubko, Maciej | - |
dc.contributor.author | Malarz, Katarzyna | - |
dc.contributor.author | Mrozek-Wilczkiewicz, Anna | - |
dc.contributor.author | Musioł, Robert | - |
dc.date.accessioned | 2022-03-01T09:56:10Z | - |
dc.date.available | 2022-03-01T09:56:10Z | - |
dc.date.issued | 2022 | - |
dc.identifier.citation | "RSC Advances" (2022), Iss. 12, art. no. 6377, s. 6377-6388 | pl_PL |
dc.identifier.issn | 2046-2069 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.12128/22764 | - |
dc.description.abstract | The 5-aminolevulinic acid (5-ALA) prodrug is widely used in clinical applications, primarily for skin cancer
treatments and to visualize brain tumors in neurosurgery. Unfortunately, its applications are limited by
unfavorable pharmacological properties, especially low lipophilicity; therefore, efficient nanovehicles are
needed. For this purpose, we synthesized and characterized two novel water-soluble fullerene
nanomaterials containing 5-ALA and D-glucuronic acid components. Their physicochemical properties
were investigated using NMR, XPS, ESI mass spectrometry, as well as TEM and SEM techniques. In
addition, HPLC and fluorescence measurements were performed to evaluate the biological activity of
the fullerene nanomaterials in 5-ALA delivery and photodynamic therapy (PDT); additional detection of
selected mRNA targets was carried out using the qRT-PCR methodology. The cellular response to the
[60]fullerene conjugates resulted in increased levels of ABCG2 and PEPT-1 genes, as determined by
qRT-PCR analysis. Therefore, we designed a combination PDT approach based on two fullerene
materials, C60-ALA and C60-ALA-GA, along with the ABCG2 inhibitor Ko143. | pl_PL |
dc.language.iso | en | pl_PL |
dc.rights | Uznanie autorstwa 3.0 Polska | * |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/pl/ | * |
dc.subject | 5-ALA | pl_PL |
dc.subject | 5-aminolevulinic acid | pl_PL |
dc.subject | [60]fullerene nanoconjugate | pl_PL |
dc.title | Synthesis and applications of [60]fullerene nanoconjugate with 5- aminolevulinic acid and its glycoconjugate as drug delivery vehicles | pl_PL |
dc.type | info:eu-repo/semantics/article | pl_PL |
dc.identifier.doi | 10.1039/d1ra08499b | - |
Pojawia się w kolekcji: | Artykuły (WNŚiT)
|