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Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12128/3305
Title: Caffeine effects on AdoR mRNA expression in Drosophila melanogaster
Authors: Francikowski, Jacek
Baran, Bartosz
Płachetka-Bożek, Anna
Krzyżowski, Michał
Augustyniak, Maria
Keywords: Adenosine receptor; mRNA; Drosophila melanogaster; Insect development; Methylxanthines
Issue Date: 2016
Citation: Open Life Science, Vol. 1, iss. 1 (2016), s. 244-249
Abstract: In this study, we aimed to evaluate whether exposure to caffeine in the early stages of development affect AdoR mRNA expression levels in the fruit fly (Drosophila melanogaster) and how this will relate to the developmental success of flies. Adenosine receptors are seen as the most important biochemical targets of caffeine. Simultaneously adenosine signaling orchestrates the development and growth of insects. We demonstrate that AdoR mRNA expression in D. melanogaster is persistent from early stages till imago. Strong alterations in AdoR expression were observed in larvae that had been treated with caffeine. However, after the imaginal molt, the differences in AdoR expression between the insects from all of the test groups evened out despite a wide range of developmental success in the groups. Taken together, these results suggest that caffeine affects the expression of its cellular targets even from the early stages of fruit fly development and thus there is a significantly lower larvae-to-adult survival rate. Moreover, we also proved that the expression of AdoR undergoes a peculiar reset during the maturation of D. melanogaster despite the conditions in which larvae developed.
URI: http://hdl.handle.net/20.500.12128/3305
DOI: 10.1515/biol-2016-0034
ISSN: 2391-5412
Appears in Collections:Artykuły (WBiOŚ)

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