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Zastosuj identyfikator do podlinkowania lub zacytowania tej pozycji: http://hdl.handle.net/20.500.12128/366
Tytuł: Adiponectin, leptin, and leptin receptor in obese patients with type 2 diabetes treated with insulin detemir
Autor: Olczyk, Paweł
Koprowski, Robert
Komosińska-Vassev, Katarzyna
Jura-Półtorak, Agnieszka
Winsz-Szczotka, Katarzyna
Kuźnik-Trocha, Kornelia
Mencner, Łukasz
Telega, Alicja
Ivanova, Diana
Olczyk, Krystyna
Słowa kluczowe: Adipocytokines; Algorithm; Diabetes mellitus type 2; Insulin detemir; Matlab; Signal processing
Data wydania: 2017
Źródło: Molecules (Basel), vol. 22, iss. 8 (2017), art. 1274
Abstrakt: The aim of the present study is to quantitatively assess the expression of selected regulatory molecules, such as leptin, leptin receptor, and adiponectin in the blood of obese patients with type 2 diabetes both before treatment and after six months of pharmacological therapy with the long-lasting insulin analogue, insulin detemir. A significant decrease in the analysed regulatory molecules, i.e., leptin receptor and adiponectin, was found in blood plasma of the patients with untreated type 2 diabetes. These changes were accompanied by an increase in plasma leptin concentrations. Insulin treatment resulted in the normalization of plasma leptin receptor and adiponectin concentrations. The circulating leptin level did not change following anti-diabetic therapy with insulin detemir. Gender was a significant factor modifying the circulating level of all the analysed regulatory active compounds. Bioinformatic analysis was performed using Matlab with the Signal Processing Toolbox. The conducted discriminant analysis revealed that the leptin receptor, Aw(19), and adiponectin, Aw(21), were the parameters undergoing the most significant quantitative changes during the six-month therapy with insulin detemir. The conducted examinations indicated the contribution of adipocytokines - the biologically-active mediators of systemic metabolism, such as leptin and adiponectin in the pathomechanism of disorders being the basis for obesity which leads to development of insulin resistance, which, in turn, results in the occurrence of type 2 diabetes.
URI: http://hdl.handle.net/20.500.12128/366
DOI: 10.3390/molecules22081274
ISSN: 1420-3049
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