Skip navigation

Zastosuj identyfikator do podlinkowania lub zacytowania tej pozycji: http://hdl.handle.net/20.500.12128/527
Tytuł: Investigating the activity spectrum for Ring-Substituted 8-Hydroxyquinolines
Autor: Musioł, Robert
Jampilek, Josef
Nycz, Jacek
Pesko, Matus
Carroll, James
Kralova, Katarina
Vejsova, Marcela
O'Mahony, Jim
Coffey, Aidan
Mrozek, Anna
Polański, Jarosław
Słowa kluczowe: In Vitro Antifungal Activity; In Vitro Antimycobacterial Activity; Lipophilicity; Pet Inhibition; Quinolines; Spinach Chloroplasts
Data wydania: 2010
Źródło: Molecules, (2010), iss. 1, p. 288-304
Abstrakt: In this study, a series of fourteen ring-substituted 8-hydroxyquinoline derivatives were prepared. The synthesis procedures are presented. The compounds were analyzed using RP-HPLC to determine lipophilicity. They were tested for their activity related to inhibition of photosynthetic electron transport (PET) in spinach (Spinacia olerácea L.) chloroplasts. Primary in vitro screening of the synthesized compounds was also performed against four mycobacterial strains and against eight fungal strains. Several compounds showed biological activity comparable with or higher than the standards isoniazid or fluconazole. For all the compounds, the relationships between the lipophilicity and the chemical structure of the studied compounds are discussed.
URI: http://hdl.handle.net/20.500.12128/527
DOI: 10.3390/molecules15010288
ISSN: 1420-3049
Pojawia się w kolekcji:Artykuły (WMFiCH)

Pliki tej pozycji:
Plik Opis RozmiarFormat 
Musiol_Investigating_the_activity_spectrum_for_Ring-Substituted_8-Hydroxyquinolines.pdf374,59 kBAdobe PDFPrzejrzyj / Otwórz
Pokaż pełny rekord


Uznanie Autorstwa 3.0 Polska Creative Commons Creative Commons