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Title: Investigating the activity spectrum for Ring-Substituted 8-Hydroxyquinolines
Authors: Musioł, Robert
Jampilek, Josef
Nycz, Jacek E.
Pesko, Matus
Carroll, James
Kralova, Katarina
Vejsova, Marcela
O'Mahony, Jim
Coffey, Aidan
Mrozek, Anna
Polański, Jarosław
Keywords: In Vitro Antifungal Activity; In Vitro Antimycobacterial Activity; Lipophilicity; Pet Inhibition; Quinolines; Spinach Chloroplasts
Issue Date: 2010
Citation: Molecules, (2010), iss. 1, p. 288-304
Abstract: In this study, a series of fourteen ring-substituted 8-hydroxyquinoline derivatives were prepared. The synthesis procedures are presented. The compounds were analyzed using RP-HPLC to determine lipophilicity. They were tested for their activity related to inhibition of photosynthetic electron transport (PET) in spinach (Spinacia olerácea L.) chloroplasts. Primary in vitro screening of the synthesized compounds was also performed against four mycobacterial strains and against eight fungal strains. Several compounds showed biological activity comparable with or higher than the standards isoniazid or fluconazole. For all the compounds, the relationships between the lipophilicity and the chemical structure of the studied compounds are discussed.
DOI: 10.3390/molecules15010288
ISSN: 1420-3049
Appears in Collections:Artykuły (WNŚiT)

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