DC pole | Wartość | Język |
dc.contributor.advisor | Gadomski, Adam | - |
dc.contributor.author | Bełdowski, Piotr | - |
dc.date.accessioned | 2018-08-27T05:48:45Z | - |
dc.date.available | 2018-08-27T05:48:45Z | - |
dc.date.issued | 2017 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.12128/5898 | - |
dc.description.abstract | This thesis presents a description of friction and lubrication mechanisms when applied to
natural system of articular cartilage. The presented model of facilitated lubrication of articular
cartilage explains a multiscale phenomenon during application of an external quasi-normal load
to the surfaces. The model is applied to explain degeneration of articular cartilage surface as
well as synovial fluid in terms of its composition. Molecular dynamics simulations as well as
analytical description are employed to describe these phenomena. Presented work is divided
into 7 chapters.
First chapter describes the theory behind friction and lubrication. The chapter consists of 5
subsections essential for understanding all occurrences in the system. First one introduces
friction and lubrication phenomenon. The basics of Soft Matter Physics as well as physiology of
articular cartilage are presented in terms of their connection to friction/lubrication mechanism.
Finally, the key factors of hydration repulsion and Grotthuss mechanism are discussed.
Second chapter presents the theory of molecular dynamics simulation and its several varieties:
full-atom, coarse grained and steered molecular dynamics.
Third section depicts a facilitated lubrication mechanism. The model is delivered by applying
dispersive kinetics as a description of PLs concentration fields. Then by modification of model
variables one can discuss a physical explanation. Finally, MNET dynamics is used to describe
dynamics of proton channels as interplay between overcrowding of protons and confinement of
a channel.
Fourth part presents on hyaluronic acid and phospholipids interactions. The literature study
provides a first step towards understanding processes occurring in normal and abnormal
synovial fluid. Results of microelectrophoresis on HA/PL complexes are presented in terms of
cross-linking mechanism as well as proton transport. Finally, molecular dynamics simulations
of HA:PL complexes are presented for different pHs and PLs concentrations. The results are
rationalized in terms of Rouse model.
Fifth chapter presents steered molecular dynamics study on micelles’ interactions and their
impact on overall process.
Sixth part presents recapitulation of all works published for this thesis and a connection between
them. The last chapter summarizes and addresses a future application of presented studies. | pl_PL |
dc.language.iso | pl | pl_PL |
dc.publisher | Katowice: Uniwersytet Śląski; Bydoszcz: Uniwersytet Technologiczno-Przyrodniczy | pl_PL |
dc.subject | biotrybologia | pl_PL |
dc.subject | chrząstka stawowa | pl_PL |
dc.title | Modelowanie komputerowe i analityczne bioinspirowanego, standardowego układu fizyki powierzchni, w zakresie tarcia i smarowania, na wybranym przykładzie | pl_PL |
dc.type | info:eu-repo/semantics/doctoralThesis | pl_PL |
Pojawia się w kolekcji: | Rozprawy doktorskie (WNŚiT)
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