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Title: Impact of D2O on peptidization of L-Cysteine
Authors: Fulczyk, Agnieszka
Łata, Eliza
Dolnik, Milos
Talik, Ewa
Kowalska, Teresa
Sajewicz, Mieczysław
Keywords: L-Cysteine; D2O; Spontaneous oscillatory peptidization; mass spectrometry; Scanning electron microscopy
Issue Date: 2018
Citation: Reaction Kinetics, Mechanisms and Catalysis, Vol. 125 (2018), s. 555–565
Abstract: An attempt was made to answer the question if spontaneous oscillatory conversion and peptidization of proteinogenic a-amino acids might be essential for living organisms. To this effect, we investigated an impact of heavy water (D2O) on the peptidization of L-Cys. As analytical techniques, we used high-performance liquid chromatography, mass spectrometry, scanning electron microscopy, and turbidimetry. The results obtained demonstrate that heavy water seriously hampers the oscillatory peptidization of L-Cys, apparently due to the presence of the deuterium cation in the reaction medium. A cautious conclusion can be drawn that thorough reflection is needed on possible importance of the oscillatory peptidization of proteinogenic a-amino acids for various different life processes.
DOI: 10.1007/s11144-018-1469-y
ISSN: 1878-5204
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