http://hdl.handle.net/20.500.12128/7295
Tytuł: | The Effects of Duodenojejunal Omega Switch in Combination with High-Fat Diet and Control Diet on Incretins, Body Weight, and Glucose Tolerance in Sprague-Dawley Rats |
Autor: | Stygar, Dominika Sawczyn, Tomasz Skrzep-Poloczek, Bronisława Owczarek, Aleksander J. Michalski, Marek Doleżych, Bogdan Mielańczyk, Łukasz Bażanów, Barbara Ziora, Paweł Choręza, Piotr Karcz, Wojciech Konrad |
Słowa kluczowe: | Bariatric surgery; DJOS surgery; obesity; Experimental rat model; Incretins; OGTT; glucose tolerance; Insulin intolerance; GIP; GLP-1 |
Data wydania: | 2018 |
Źródło: | Obesity Surgery, Vol. 28, iss. 3 (2018), s. 748-759 |
Abstrakt: | Background: Despite excellent results of bariatric surgery in the treatment of type 2 diabetes and weight loss in human subjects, some patients do not obtain desired results. One of the reasons for this is that not all patients follow caloric intake recommendations. Aim: The aim of this study was to investigate the effect of duodenojejunal omega switch (DJOS) surgery on body weight, glucose tolerance, and incretins in rats. Methods: DJOS and SHAM surgery were performed on rats maintained for 8 weeks on high-fat diet (HF) and control diet (CD), respectively. After surgery, four groups were kept on the same diet as before the surgery, and four groups had a changed diet (CD vs. HF and HF vs. CD) for the next 8 weeks. Glucose tolerance, insulin tolerance, glucose-stimulated insulin, glucagon-like peptide-1 (GLP-1) and gastric inhibitory polypeptide/glucose-dependent insulinotropic polypeptide (GIP) secretion, food intake, and body weight were measured. Results: A change of diet after surgery resulted in reduced glucose tolerance. Plasma insulin levels were lowered between DJOS and SHAM surgeries for the HF/HF and CD/HF groups. DJOS surgery did not reduce body weight in the studied groups, irrespective of diet. In the HF/HF group, ΔGLP-1 was lower for DJOS surgery in comparison with other groups. Differences of weight changes were observed for groups HF/HF and HF/CD. After DJOS surgery, ΔGIP was lower in the CD/HF group compared with HF/HF. Conclusions: Our results show that applications of different types of diets, before and after surgery, is a sensitive method for studies of mechanism of glucose intolerance after DJOS surgery. |
URI: | http://hdl.handle.net/20.500.12128/7295 |
DOI: | 10.1007/s11695-017-2883-3 |
ISSN: | 0960-8923 |
Pojawia się w kolekcji: | Artykuły (WNP) |
Plik | Opis | Rozmiar | Format | |
---|---|---|---|---|
Stygar_The_effects_of_duodenojejunal_omega_switch.pdf | 2,06 MB | Adobe PDF | Przejrzyj / Otwórz |
Uznanie Autorstwa 3.0 Polska Creative Commons