DC pole | Wartość | Język |
dc.contributor.author | Bębenek, Ewa | - |
dc.contributor.author | Jastrzębska, Maria | - |
dc.contributor.author | Kadela-Tomanek, Monika | - |
dc.contributor.author | Chrobak, Elwira | - |
dc.contributor.author | Orzechowska, Beata | - |
dc.contributor.author | Zwolińska, Katarzyna | - |
dc.contributor.author | Latocha, Małgorzata | - |
dc.contributor.author | Mertas, Anna | - |
dc.contributor.author | Czuba, Zenon | - |
dc.contributor.author | Boryczka, Stanisław | - |
dc.date.accessioned | 2019-03-19T09:56:22Z | - |
dc.date.available | 2019-03-19T09:56:22Z | - |
dc.date.issued | 2017 | - |
dc.identifier.citation | Molecules (Basel), 2017, iss. 11, art. no. 1876, s. 1-16 | pl_PL |
dc.identifier.issn | 1420-3049 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.12128/8602 | - |
dc.description.abstract | Betulin derivatives containing a 1,2,3-triazole ring possess a wide spectrum of biological
activities, including antiviral, anticancer, and antibacterial activity. A series of novel triazoles were
prepared by the 1,3-dipolar cycloaddition reaction between the alkyne derivatives of betulin and
organic azides. The chemical structures of the obtained compounds were defined by 1H and 13C
NMR, IR, and high-resolution mass spectrometry (HR-MS) analysis. The target triazoles were
screened for their antiviral activity against DNA and RNA viruses. The cytotoxic activity of the
obtained compounds 5a–k and 6a–h was determined using five human cancer cell lines (T47D,
MCF-7, SNB-19, Colo-829, and C-32) by a WST-1 assay. The bistriazole 6b displayed a promising IC50
value (0.05 M) against the human ductal carcinoma T47D (500-fold higher potency than cisplatin).
The microdilution method was applied for an evaluation of the antimicrobial activity of all of the
compounds. The triazole 5e containing a 30-deoxythymidine-50-yl moiety exhibited antibacterial
activity against two gram-negative bacteria vz. Klebsiella pneumoniae and Escherichia coli (minimal
inhibitory concentration (MIC) range of 0.95–1.95 M). | pl_PL |
dc.language.iso | en | pl_PL |
dc.rights | Uznanie autorstwa 3.0 Polska | * |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/pl/ | * |
dc.subject | betulin | pl_PL |
dc.subject | 1,3-dipolar cycloaddition | pl_PL |
dc.subject | triazoles | pl_PL |
dc.subject | antiviral activity | pl_PL |
dc.subject | anticancer activity | pl_PL |
dc.subject | antimicrobial activity | pl_PL |
dc.title | Novel triazole hybrids of betulin : synthesis and biological activity profile | pl_PL |
dc.type | info:eu-repo/semantics/article | pl_PL |
dc.relation.journal | Molecules (Basel) | pl_PL |
dc.identifier.doi | 10.3390/molecules22111876 | - |
Pojawia się w kolekcji: | Artykuły (WNŚiT)
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